European Journal of Clinical Pharmacology

, Volume 34, Issue 6, pp 619–623

Lack of potentiation by cetirizine of alcohol — Induced psychomotor disturbances

  • M. Doms
  • G. Vanhulle
  • Y. Baelde
  • P. Coulie
  • P. Dupont
  • J. -P. Rihoux
Originals

DOI: 10.1007/BF00615227

Cite this article as:
Doms, M., Vanhulle, G., Baelde, Y. et al. Eur J Clin Pharmacol (1988) 34: 619. doi:10.1007/BF00615227

Summary

The possible interaction between cetirizine 2HCl and alcohol was studied in a double-blind, cross-over trial in 36 healthy volunteers. The performance of each volunteer was tested with a battery of five objective psychometric tests, and their subjective feelings were evaluated by visual analogue scales, and by extensive questionnaire.

The psychomotor performance and subjective inventory of health was significantly impaired by alcohol intake. Cetirizine 2HCl was not different from placebo. There was no adverse interaction between cetirizine 2HCl and alcohol.

Cetirizine and alcohol did not modify each others blood levels.

Key words

cetirizine 2HCl alcohol drug interference plasma levels psychomotor performance 

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • M. Doms
    • 1
  • G. Vanhulle
    • 1
  • Y. Baelde
    • 2
  • P. Coulie
    • 2
  • P. Dupont
    • 2
  • J. -P. Rihoux
    • 2
  1. 1.Rogil Field Research CentrumLinden
  2. 2.UCB S.A.Braine-L'AlleudBelgium

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