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Excretion of noscapine in human breast milk

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Summary

The excretion of noscapine in human breast milk was studied in 8 lactating women given a single oral dose of 100 or 150 mg after a light breakfast. Serum and milk samples were collected for 24 h after drug intake. Although noscapine is a weak base, only a small amount was excreted in the milk. The median milk/serum ratio was 0.29, range 0.15–0.88. The noscapine dose received by a child during a 24 hour period, when the maternal dose is 50 mg t.i.d., was calculated to be 0.8 (0.4–1.9) µg/kg (median and range).

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Olsson, B., Bolme, P., Dahlström, B. et al. Excretion of noscapine in human breast milk. Eur J Clin Pharmacol 30, 213–215 (1986). https://doi.org/10.1007/BF00614306

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Key words

  • noscapine
  • lactation
  • excretion
  • breast feeding