The excretion of noscapine in human breast milk was studied in 8 lactating women given a single oral dose of 100 or 150 mg after a light breakfast. Serum and milk samples were collected for 24 h after drug intake. Although noscapine is a weak base, only a small amount was excreted in the milk. The median milk/serum ratio was 0.29, range 0.15–0.88. The noscapine dose received by a child during a 24 hour period, when the maternal dose is 50 mg t.i.d., was calculated to be 0.8 (0.4–1.9) µg/kg (median and range).
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Bickerman HA (1978) Antitussive drugs. In: Modell W (ed) Drugs of choice. CV Mosby, St. Louis
Matthys H, Erhardt J, Ruhle K-H (1985) Objektivierung der Wirkung von Antitussiva mittels Tussometrie an Patienten mit chronischem Husten. Schweiz Med Wochenschr 115: 307–311
Dahlström B, Mellstrand T, Löfdahl CG, Johansson M (1982) Pharmacokinetic properties of noscapine. Eur J Clin Pharmacol 22: 535–539
Vedsö S (1961) Absorption and excretion of noscapine. Acta Pharmacol Toxicol 18: 157–164
Johansson M, Eksborg S, Arbin A (1983) Determination of noscapine in plasma by liquid chromatography. J Chromatogr 275: 355–366
Illingworth RS (1979) Common symptoms of disease in children, 6th edn. Blackwell Scientific Publications, Oxford
Lentner CL (ed) (1981) Geigy scientific tables, vol 1. Ciba-Geigy, Basel
About this article
Cite this article
Olsson, B., Bolme, P., Dahlström, B. et al. Excretion of noscapine in human breast milk. Eur J Clin Pharmacol 30, 213–215 (1986). https://doi.org/10.1007/BF00614306
- breast feeding