Disposition of quercetin in man after single oral and intravenous doses

  • R. Gugler
  • M. Leschik
  • H. J. Dengler


The pharmacokinetics of quercetin, a flavonoid, have been studied in 6 volunteers after single intravenous (100 mg) and oral (4 g) doses. The data after iv administration were analyzed according to a two compartment open model with half lives of 8.8±1.2 min for the α phase and 2.4±0.2 h for the β phase (predominant half life), respectively. Protein binding was >98%. The apparent volume of distribution was small at 0.34±0.03 l/kg. Of the intravenous dose 7.4±1.2% was excreted in urine as a conjugated metabolite, and 0.65±0.1% was excreted unchanged. After oral administration no measurable plasma concentrations could be detected, nor was any quercetin found in urine, either unchanged or in a metabolized form. These results exclude absorption of more than 1% of unchanged drug. Recovery in faeces after the oral dose was 53±5%, which suggests extensive degradation by microorganisms in the gut. The data obtained show that oral administration of flavonoids may be of questionable value.

Key words

Quercetin flavonoids pharmacokinetics absorption disposition metabolism man 


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • R. Gugler
    • 1
  • M. Leschik
    • 1
  • H. J. Dengler
    • 1
  1. 1.Departments of MedicineUniversities of Giessen and BonnFederal Republic of Germany

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