Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man

  • O. Penttilä
  • H. Hurme
  • P. J. Neuvonen


A possible interaction between zinc sulphate and tetracycline or doxycycline was examined in a cross-over study in seven volunteers. A single dose of zinc sulphate (45 mg Zn++) was given simultaneously with tetracycline hydrochloride (500 mg) or doxycycline chloride (200 mg). The serum concentration of tetracycline, the area under the serum tetracycline concentration-time curve and the excretion of tetracycline in urine were reduced by about 30% (p<0.05) from the respective control values. The absorption of doxycycline was not influenced significantly by zinc sulphate. The clinical significance of the zinc-tetracycline interaction seems to be of limited importance.

Key words

Drug interaction drug absorption zinc sulphate tetracycline doxycycline 


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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • O. Penttilä
    • 1
  • H. Hurme
    • 1
  • P. J. Neuvonen
    • 1
  1. 1.Maria Hospital and Department of Clinical PharmacologyUniversity of HelsinkiFinland

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