Effect of preoperative paracetamol on pain after oral surgery
- 67 Downloads
A double-blind, randomized cross-over trial was carried out in 50 patients undergoing surgical removal of bilaterally impacted lower wisdom teeth. Surgery in each patient was performed twice and paracetamol 1000 mg was administered once preoperatively and once postoperatively. The time interval to additional analgesic intake and the pain intensity up to and at that time were assessed. There was no difference between the 2 treatments. It was concluded that preoperative paracetamol does not offer any clinical advantage in patients who undergo surgical removal of impacted lower wisdom teeth.
Key wordsparacetamol preoperative administration postoperative administration analgesic activity cross-over study oral surgery
Unable to display preview. Download preview PDF.
- 1.Dionne RA, Cooper SA (1978) Evaluation of preoperative ibuprofen for postoperative pain after removal of third molars. Oral Surg 45: 851–856Google Scholar
- 2.Løkken P, Olsen I, Bruaset I, Norman-Pedersen K (1975) Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation. A test with ibuprofen. Eur J Clin Pharmacol 8: 209–216Google Scholar
- 3.Mielke CH, Heiden D, Britten AF, Ramos J, Flavell P (1976) Hemostasis, antipyretics, and mild analgesics. Acetaminophen vs Aspirin. J Am Med Assoc 235: 613–616Google Scholar
- 4.Ohnhaus EE, Adler R (1975) Methodological problems in the measurement of pain. A comparison between the verbal rating scale and the visual analogue scale. Pain 1: 379–384Google Scholar
- 5.Petersen JK (1978) The analgesic and antiinflammatory efficacy of diflunisal and codeine after removal of impacted third molars. Curr Med Res Opin 5: 525–535Google Scholar
- 6.Quiding H, Oksala E, Happonen RP, Lehtimäki K, Ojala T (1981) The visual analogue scale in multiple dose evaluations of analgesics. J Clin Pharmacol 21: 424–429Google Scholar
- 7.Scott J, Huskisson EC (1976) Graphic representation of pain. Pain 2: 175–184Google Scholar
- 8.Skjelbred P, Løkken P (1977) Acetylsalicylic acid vs paracetamol. Effects on post-operative course. Eur J Clin Pharmacol 12: 257–264Google Scholar
- 9.Skjelbred P, Løkken P (1979) Paracetamol versus placebo. Effects on post-operative course. Eur J Clin Pharmacol 15: 27–33Google Scholar
- 10.Stenbjerg S, Petersen JK (1980) Platlet function and fibrinolytic activity after a single dose of diflunisal (Donobid). Int J Oral Surg 9: 472–476Google Scholar
- 11.Wang RIH, Warte E (1981) Crossover and parallel study of oral analgesics. J Clin Pharmacol 21: 162–168Google Scholar