The specificity of the K-channels which are present in the ciliated membrane of ampullar receptors has been investigated by replacing K+ in the fluids bathing the canal with Rb+ and Cs+. Results show that, unlike Cs+, Rb+ is able to substitute K+ in maintaining the receptor function. These findings favour the hypothesis that the transduction channels which allow the receptor current to flow across sensory cell bodies are specific K-channels. The effects of Rb+ and Cs+ on primary sensory neuron endings were also studied.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
- Adc :
slow ampullar potentials
- Ndc :
slow nerve potentials
Adams DJ, Dwyer TM, Hille B (1980) The permeability of endplate channels to monovalent and divalent metal cations. J Gen Physiol 75:493–510
Bezanilla F, Armstrong CM (1972) Negative conductance caused of sodium and cesium ions into the potassium channels of squid axons. J Gen Physiol 60:588–608
Corey DP, Hudspeth AJ (1979) Ionic basis of the receptor potential in a vertebrate hair cell. Nature 281:675–677
Goto K, Takahashi T, Miyamae S, Sudo S (1982) Effects of Rb and Cs on the electrogenic Na-pump in rabbit sinoatrial node cells. Jpn J Physiol 32:843–854
Hille B (1973) Potassium channels in myelinated nerve: selective permeability to small cations. J Gen Physiol 61:669–686
Konishi T, Kelsey E, Singleton GT (1966) Effects of chemical alteration in the endolymph on the cochlear potentials. Acta Otolaryngol (Stockh) 62:393–404
Miller SS, Steinberg RH (1982) Potassium transport across the frog retinal pigment epithelium. J Membrane Biol 67:199–209
Ohmori H (1984) Studies of ionic currents in the isolated vestibular hair cell of the chick. J Physiol (Lond) 350:561–581
Russel I, Sellick PM (1976) Measurement of potassium and chloride ion concentration in the cupulae of lateral line ofXenopus laevis. J Physiol (Lond) 257:245–255
Standen NB, Stanfield PR (1980) Rubidium block and rubidium permeability of the inward rectifier of frog skeletal muscle fibres. J Physiol (Lond) 304:415–435
Swenson RP, Armstrong CM (1981) K+ channels close more slowly in the presence of external K+ and Rb+. Nature 291:427–429
Taglietti V, Rossi ML, Casella C (1977) Adaptive distortions in the generator potential of semicircular canal sensory afferent. Brain Res 123:41–57
Valli P, Zucca G (1976) The origin of slow potentials in semicircular canals of the frog. Acta Otolaryngol (Stockh) 81:395–405
Valli P, Zucca G, Casella C (1977) The importance of potassium in the function of frog semicircular canals. Acta Otolaryngol (Stockh) 84:344–351
Valli P, Zucca G, Casella C (1979) Ionic composition of the endolymph and sensory transduction in labyrinthine organs. Acta Otolaryngol (Stockh) 87:466–471
Zucca G, Valli P, Casella C (1982) Ionic mechanisms sustaining activity in ampullar receptors of the frog. Acta Otolaryngol (Stockh) 93:355–362
About this article
Cite this article
Valli, P., Zucca, G., Botta, L. et al. Specificity of the K-channels in labyrinthine organs: effects of Rb+ and Cs+ on the conversion process in frog semicircular canals. J. Comp. Physiol. 155, 739–743 (1984). https://doi.org/10.1007/BF00611590
- Cell Body
- Sensory Neuron
- Receptor Function
- Conversion Process
- Semicircular Canal