A double blind controlled study was conducted on 8 healthy adult volunteers to assess the effects of repeated doses of the histamine antagonist, triprolidine, on performance tests and subjective feelings. A comparison was made between the effects of triprolidine 5 mg and lactose dummy using four different treatment schedules under double blind conditions. Subjects were treated on two consecutive days each week for four weeks. A schedule of tests was given on each of the treatment days and results were analysed by the method of analysis of variance, values of p<0.05 being taken as significant. Following triprolidine, impairment occurred in all performance tests, specifically, auditory vigilance, short term memory, reaction time, digit symbol substitution and tapping. Similarly there was significant mental and physical sedation. Evidence of a reduced effect of triprolidine on day 2 when triprolidine drug had been given on day 1 occurred in the tapping test and the change in mental sedation from pre to post treatment. However in all tests and subjective ratings the effect of triprolidine on day 2 was lessened by pretreatment with triprolidine on day 1, though this only achieved significance in the two variables mentioned. No evidence for increased effect of drug due to cumulation was obtained. It was concluded that tolerance to the effect of triprolidine on the nervous system begins to occur within 24 h with repeated dosing.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Aitken, R.C.B.: A growing edge of measurement of feelings. Proc. roy. Soc. Med.62, 989–993 (1969)
Bye, C., Dewsbury, D., Peck, A.W.: Effects on the human central nervous system of two isomers of ephedrine and triprolidine and their interaction. Brit. J. clin. Pharmacol.1, 71–78 (1974)
Hart, J., Hill, H.M., Bye, C.E., Wilkinson, R.T. and Peck, A.W.: The effects of amylobarbitone sodium and diazepam on human performance. Brit. J. clin. Pharmacol.3, 289–298 (1976)
Lader, M.H., Norris, H.: The effects of nitrous oxide on the human auditory evoked response. Psychopharmacologia (Berl.)16, 115–127 (1969)
Melville, K.I.: in: Histamine and antihistamines. International Encyclopaedia of Pharmacology and Therapeutics. London: Pergamon Press 1973
Norris, H.: The actions of sedatives on brain stem oculomotor systems in man. Neuropharmacology10, 181–189 (1971)
Peck, A.W., Fowle, A.S.E. and Bye, C.: A comparison of triprolidine and clemastine on histamine antagonists and performance tests in man: implications for the mechanism of drug induced drowsiness. Europ. J. clin. Pharmacol.8, 455–463 (1975)
Wechsler, D.: Manual for the Wechsler adult intelligence scale, p. 44. New York: Psychological Corporation; London: National Foundation for Educational Research 1955
Wilkinson, R.T.: Methods for research on sleep deprivation and sleep function. Int. Psychiat. clin.7, 369–382 (1970)
About this article
Cite this article
Bye, C.E., Claridge, R., Peck, A.W. et al. Evidence for tolerance to the central nervous effects of the histamine antagonist, triprolidine, in man. Eur J Clin Pharmacol 12, 181–186 (1977). https://doi.org/10.1007/BF00609857
- Histamine antagonists
- central nervous effects
- normal volunteers