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Journal of comparative physiology

, Volume 147, Issue 2, pp 189–194 | Cite as

Patterns of synaptic inhibition in motoneurons and interneurons during fictive swimming in the lamprey, as revealed by Cl injections

  • Jonathan A. Kahn
Article

Summary

During fictive swimming in the isolated spinal cord of the lamprey (Ichthyomyzon unicuspis andPetromyzon marinus) the membrane potentials of motoneurons (MNs), lateral interneurons (L INs), and CC interneurons (CC INs) oscillate between a depolarised and a relatively hyperpolarised phase. After intracellular Cl injections (usually combined with a DC hyperpolarisation) IPSP's became depolarising, and in cells which were phasically inhibited, phases of relative hyperpolarisation became phases of relative depolarisation. The peak depolarisation and/or spike burst mid point in MNs after Cl injection occurred at a phase of 0.65 ± 0.12 (mean ±S.D.) in the cycle, with zero being the start of the ipsilateral ventral root burst. In CC INs the peak depolarisation and/or spike burst mid point after Cl occurred significantly earlier, at a phase of 0.40 ± 0.18. L INs were also phasically inhibited with peak depolarisation and/or spike burst mid point after Cl injection at an intermediate phase of 0.52 ± 0.21. It is concluded that the central pattern generator for fictive swimming has at least three synaptic outputs: an early excitation, and inhibition at a range of phases, which could be combinations of an early and a late inhibition.

Keywords

Spinal Cord Membrane Potential Pattern Generator Late Inhibition Intermediate Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CC IN

interneuron with contralateral caudal axon

MN

motoneuron

L IN

lateral interneuron

VR

ventral root

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Jonathan A. Kahn
    • 1
  1. 1.Department of Physiology and BiophysicsWashington University School of MedicineSt. LouisUSA

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