Advertisement

European Journal of Clinical Pharmacology

, Volume 13, Issue 2, pp 153–155 | Cite as

Effect of capsule colour and order of administration of hypnotic treatments

  • P. E. Lucchelli
  • A. D. Cattaneo
  • J. Zattoni
Originals

Summary

Ninety-six hospitalized insomniac patients were asked to compare by a daily questionnaire the effect on sleep of the colour of the capsules and the order of administration of two treatments — heptabarbital and placebo. A balanced incomplete-block design was used; sleep onset time and sleep duration time were the main criteria of assessment. There was a significant interaction of colour and order of administration with sex. The placebo response was positive in 36% of instances.

Key words

Heptabarbital drug colour order of administration sex-linked response placebo response rate 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Cattaneo, A.D., Lucchelli, P.E., Filippucci, G.: Sedative effects of placebo treatment. Europ. J. clin. Pharmacol.3, 43–45 (1970)Google Scholar
  2. 2.
    Hare, E.H.: Comparative efficacy of hypnotics. A self-controlled, self-recorded clinical trial in neurotic patients. Brit. J. prev. soc. Med.9, 140–149 (1955)Google Scholar
  3. 3.
    Exton-Smith, A.N., Hodkinson, H.M., Cromie, B.W.: Controlled comparison of four sedative drugs in elderly patients. Brit. med. J.1963/2, 1037–1040Google Scholar
  4. 4.
    Sunshine, A., Laska, E., Meisner, M., Morgan, S.: Analgesic studies of indomethacin as analyzed by computer techniques. Clin. Pharmacol. Ther.5, 699–707 (1964)Google Scholar
  5. 5.
    Kantor, T.G., Sunshine, A., Laska, E., Meisner, M., Hopper, M.: Oral analgesic studies: pentazocine hydrochloride, codeine, aspirin, and placebo and their influence on response to placebo. Clin. Pharmacol. Ther.7, 447–454 (1966)Google Scholar
  6. 6.
    Shapira, K., Mc Clelland, H.A., Griffiths, N.R., Newell, D.J.: Study on the effects of tablet colour in the treatment of anxiety states. Brit. med. J.1970/2, 446–449Google Scholar
  7. 7.
    Huskisson, E.C.: Simple analgesics for arthritis. Brit. med. J.1974/2, 196–200Google Scholar
  8. 8.
    Lasagna, L.: A study of hypnotic drugs in patients with chronic diseases. J. chronic Dis.3, 122–133 (1956)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • P. E. Lucchelli
    • 1
    • 2
  • A. D. Cattaneo
    • 1
  • J. Zattoni
    • 1
  1. 1.Department of AnaesthesiologyUniversity of Genoa Medical SchoolGenoaItaly
  2. 2.Smith Kline & French S.p.A.MilanoItalia

Personalised recommendations