European Journal of Clinical Pharmacology

, Volume 13, Issue 2, pp 153–155 | Cite as

Effect of capsule colour and order of administration of hypnotic treatments

  • P. E. Lucchelli
  • A. D. Cattaneo
  • J. Zattoni


Ninety-six hospitalized insomniac patients were asked to compare by a daily questionnaire the effect on sleep of the colour of the capsules and the order of administration of two treatments — heptabarbital and placebo. A balanced incomplete-block design was used; sleep onset time and sleep duration time were the main criteria of assessment. There was a significant interaction of colour and order of administration with sex. The placebo response was positive in 36% of instances.

Key words

Heptabarbital drug colour order of administration sex-linked response placebo response rate 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • P. E. Lucchelli
    • 1
    • 2
  • A. D. Cattaneo
    • 1
  • J. Zattoni
    • 1
  1. 1.Department of AnaesthesiologyUniversity of Genoa Medical SchoolGenoaItaly
  2. 2.Smith Kline & French S.p.A.MilanoItalia

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