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Effect of Calcium Entry Blockade on ethanol-induced changes in bronchomotor tone

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The effect of various Calcium Entry Blockers (CEBs; nifedipine, flunarizine, diltiazem, verapamil) on ethanol-induced bronchoconstriction was studied in normal healthy volunteers. Nifedipine and diltiazem inhibited the bronchoconstriction and verapamil and flunarizine had no effect. The data favour the general hypothesis of differential tissue sensitivity to the various CEBs. The activity of CEBs on bronchomotor tone may be of therapeutic value in patients in whom bronchodilator activity is recommended in addition to the cardiovascular action.

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  1. Geppert EF, Boushey HA (1978) An investigation of the mechanism of ethanol-induced bronchoconstriction. Am Rev Respir Dis 118: 135–139

  2. Gong H Jr, Tashkin DP, Calvarese BM (1981) Alcohol-induced bronchospasm in an asthmatic patients. Chest 80: 167–173

  3. Henderson AF, Heaton RW, Dunlop LS, Costello JF (1978) Effect of nifedipine on antigen-induced bronchoconstriction. Am Rev Respir Dis 127: 549–553

  4. Kundson RJ, Lebowitz MD (1983) Maximal mid-expiratory flow (FEF25–75%): normal limits and assessment of sensibility. Am Rev Respir Dis 117: 609

  5. Nayler WG, Horowitz JD (1983) Calcium antagonists: a new class of drugs. Pharmacol Ther 20: 203–262

  6. Pennock BE, Rogers RM, McCaffree R (1981) Changes in measured spirometric indices. What is significant? Chest 80: 97–99

  7. Spedini C, Lombardi C, Trabucchi M (1983) Bronchoconstriction after ethanol inhalation: hypotetic role of histamine. It J Chest Dis 36: 373–376

  8. Williams DO, Barnes PJ, Vickers HP, Rudolf M (1981) Effect of nifedipine on bronchomotor tone and histamine reactivity in asthma. Br Med J 283: 348

  9. Zuskin E, Bouhuys A, Saric M (1981) Lung function changes by ethanol inhalation. Clin Allergy 11: 243–248

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Lombardi, C., Spedini, C. & Govoni, S. Effect of Calcium Entry Blockade on ethanol-induced changes in bronchomotor tone. Eur J Clin Pharmacol 28, 221–222 (1985). https://doi.org/10.1007/BF00609695

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Key words

  • calcium entry blockers
  • bronchomotor tone
  • ethanol
  • nifedipine
  • flunarizine
  • diltiazem
  • verapamil
  • healthy volunteers