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Failure of TRH and ORG 2766 hexapeptide to counteract alcoholic inebriation in man

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The actions and interactions of alcohol (1.5 g/kg) and two stimulant peptides were investigated in healthy volunteers. Double blind and cross over studies in 8 subjects, at one-week intervals, revealed that ORG 2766 (5 or 20 mg i.m.) and particularly TRH (10 µg/kg i.v.) enhanced rather than antagonized alcohol-induced inebriation. The interactions were associated with elevated breath alcohol concentrations. Similar studies with 8 other subjects showed that peptides given in combination with a non-alcoholic drink tended to impair performance assessed as various psychophysiological variables. However, ORG 2766 5 mg was subjectively rated as producing a feeling of improved performance.

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Linnoila, M., Mattila, M.J., Karhunen, P. et al. Failure of TRH and ORG 2766 hexapeptide to counteract alcoholic inebriation in man. Eur J Clin Pharmacol 21, 27–32 (1981). https://doi.org/10.1007/BF00609584

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Key words

  • alcohol
  • peptides
  • ORG 2766
  • TRH
  • inebriation
  • psychomotor performance