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European Journal of Clinical Pharmacology

, Volume 30, Issue 6, pp 705–708 | Cite as

Pharmacokinetics of albendazole in man

  • S. E. Marriner
  • D. L. Morris
  • B. Dickson
  • J. A. Bogan
Originals

Summary

The pharmacokinetics of albendazole were investigated in healthy volunteers and in patients receiving albendazole for treatment of hydatid disease. Unchanged albendazole was below detectable limits in plasma, urine, bile and cyst fluid. The major metabolite present in all fluids was the sulfoxide. Maximum concentrations of albendazole sulfoxide in plasma were very variable, probably due to variable absorption of albendazole.

Key words

albendazole hydatid disease pharmacokinetics man 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • S. E. Marriner
    • 1
  • D. L. Morris
    • 2
  • B. Dickson
    • 3
  • J. A. Bogan
    • 1
  1. 1.Department of Veterinary PharmacologyUniversity of Glasgow Veterinary SchoolBearsden, GlasgowUK
  2. 2.The General HospitalBirminghamUK
  3. 3.Overseas Medical DivisionSmith, Kline and French LaboratoriesWelwyn Garden CityUK

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