European Journal of Clinical Pharmacology

, Volume 30, Issue 4, pp 505–507 | Cite as

Spiramycin has no effect on serum theophylline in asthmatic patients

  • D. Debruyne
  • A. Jehan
  • M. -C. Bigot
  • B. Lechevalier
  • J. -N. Prevost
  • M. Moulin
Short Communications


Fifteen asthmatic patients receiving a sustained-release theophylline preparation were also treated with spiramycin for at least 5 days. The macrolide antibiotic had no significant effect on the steady-state theophylline concentration, unlike erythromycin and troleandomycin, which belong to the same class of antibiotics. The latter two drugs have different chemical structures and decrease theophylline clearance. Accordingly, spiramycin comedication does not require special serum level drug monitoring or adjustment of the dose of theophylline.

Key words

theophylline spiramycin drug interaction theophylline serum level monitoring 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • D. Debruyne
    • 1
  • A. Jehan
    • 2
  • M. -C. Bigot
    • 1
  • B. Lechevalier
    • 2
  • J. -N. Prevost
    • 2
  • M. Moulin
    • 1
  1. 1.Laboratory of PharmacologyUniversity Hospital Center of CaenCaenFrance
  2. 2.Division of PneumologyUniversity Hospital Center of CaenCaenFrance

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