European Journal of Clinical Pharmacology

, Volume 30, Issue 4, pp 503–504

Acceptance of antibiotic mixtures by infants and children

  • M. Uhari
  • L. Eskelinen
  • J. Jokisalo
Short Communications

Summary

The acceptance by children of two pharmacologically identical phenoxymethyl-penicillin potassium and erythromycin ethylsuccinate mixtures, differing only in their flavouring agents, was compared in a randomised blind manner. The time a nurse required to give the drug to a child was recorded and a score of the acceptance was given by the nurse. The mean time to give erythromycin Brand 1 was 29 s (SD±21, number of children=20) and mean time to give Brand 2 it was 16 s (SD±13,n=18); the difference was significant (p<0.05). The mean scores were 2.9 (SD±0.025). The difference between the two penicillin products was not significant. The time required to give a medicine was a useful way to compare the effect of different flavouring mixtures on the acceptance of drugs by infants and children.

Key words

drug acceptance antibiotics flavouring agents children infants measurement methods 

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. Uhari
    • 1
  • L. Eskelinen
    • 1
  • J. Jokisalo
    • 1
  1. 1.Department of PediatricsUniversity of Oulu and the Hospital Pharmacy, University Central Hospital of OuluOuluFinland

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