European Journal of Clinical Pharmacology

, Volume 30, Issue 4, pp 503–504 | Cite as

Acceptance of antibiotic mixtures by infants and children

  • M. Uhari
  • L. Eskelinen
  • J. Jokisalo
Short Communications


The acceptance by children of two pharmacologically identical phenoxymethyl-penicillin potassium and erythromycin ethylsuccinate mixtures, differing only in their flavouring agents, was compared in a randomised blind manner. The time a nurse required to give the drug to a child was recorded and a score of the acceptance was given by the nurse. The mean time to give erythromycin Brand 1 was 29 s (SD±21, number of children=20) and mean time to give Brand 2 it was 16 s (SD±13,n=18); the difference was significant (p<0.05). The mean scores were 2.9 (SD±0.025). The difference between the two penicillin products was not significant. The time required to give a medicine was a useful way to compare the effect of different flavouring mixtures on the acceptance of drugs by infants and children.

Key words

drug acceptance antibiotics flavouring agents children infants measurement methods 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. Uhari
    • 1
  • L. Eskelinen
    • 1
  • J. Jokisalo
    • 1
  1. 1.Department of PediatricsUniversity of Oulu and the Hospital Pharmacy, University Central Hospital of OuluOuluFinland

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