Twenty patients with essential hypertension were given 400 mg acebutolol once daily for 24 weeks. In order to study if side effects resembling the “Practolol syndrome” developed, ocular effects were sought and antinuclear antibody (ANA) in blood was assessed before and after treatment. ANA was negative both before and after the study in 17 patients; in one patient ANA was positive, but the titre (1:10) was low and did not change during the study. Acebutolol produced no undesirable effects on cornea, conjunctiva or lens. During acebutolol treatment, tear secretion was reduced but tear lysozyme concentration was not significantly altered. Overall, acebutolol had no undesirable action similar to the practolol-induced syndrome, nor did it cause such common clinical ocular symptoms such as dry or gritty eyes.
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Booth RJ, Willson JD, Bullock JY (1982)β-Adrenergic receptor blockers and antinuclear antibodies in hypertension. Clin Pharmacol Ther 31: 555–558
Cody RJ, Calabrese LH, Clough JD, Tarazi RC, Bravo EL (1979) Development of antinuclear antibodies during acebutolol therapy. Clin Pharmacol Ther 25: 800–805
Cubey RB, Taylor SH (1975) Ocular reaction to propranolol and resolution on continued treatment with different beta-blocking drug. Br Med J 4: 327–328
Felix RH, Ive FA, Dahl MGC (1974) Cutaneous and ocular reactions to practolol. Br Med J 4: 321–324
Friou GI (1957) Clinical application of lupus serum-nucleoprotein reaction using fluorescent antibody technique. J Clin Invest 36: 890
Mackie IA, Seal DV, Pescod JM (1977) Beta-adrenergic receptor blocking drugs: tear lysozyme and immunological screening for adverse reaction. Br J Ophthalmol 61: 354–359
Raftery EB, Denman AM (1973) Systemic lupus erythematosus syndrome induced by practolol. Br Med J 2: 452–455
Richardson PJ, Tee DEH, Oram S (1975) Oculocutaneous reactions to beta-blocking drugs. Br Med J 4: 648
Shapiro A, Kimchi A, Gotsman MS, Lewis BS (1980) Ocular effects of acebutolol and propranolol. Met Ped Ophthalmol 4: 87–88
Wright P (1975) Untoward effects associated with practolol administration: oculomucocutaneous syndrome. Br Med J 1: 595–598
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Sekine, K., Takahashi, M., Ogata, E. et al. Antihypertensive therapy with a single daily dose of acebutolol in essential hypertension, response and ophthalmological assessment in the Japanese. Eur J Clin Pharmacol 28, 709–711 (1985). https://doi.org/10.1007/BF00607921
- antinuclear antibody
- practolol syndrome
- ocular examination