Excretion of paracetamol in human breast milk
- 115 Downloads
Breast milk and plasma levels of paracetamol were monitored in 3 lactating women after ingestion of a single 500 mg dose of paracetamol. The paracetamol concentrations were consistently lower in milk, with a mean milk/plasma AUC ratio of 0.76. This value was in close agreement with the milk/plasma partition ratio of 0.81 foundin vitro, and could be related to quantitative binding differences between the two fluids. The half-lives of paracetamol in plasma and breast milk were almost identical, with an overall mean of 2.7 h. As less than 0.1% of the maternal dose would be present in 100 ml milk, breast feeding need not be discontinued due to paracetamol treatment in conventional dosage.
Key wordsparacetamol breast milk plasma drug excretion in breast milk protein binding
Unable to display preview. Download preview PDF.
- 1.Weder HG, Schildknecht J, Kesselring P (1971) A new equilibrium dialysing system. Am Lab 10: 15–21Google Scholar
- 2.Ehrnebo M, Agurell S, Boreus LO, Gordon E, Lönrot U (1974) Pentazocine binding to blood cells and plasma proteins. Clin Pharmacol Ther 16: 424–429Google Scholar
- 3.Rawlins MD, Henderson DB, Hijab AR (1977) Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharmacol 11: 283–286Google Scholar
- 4.Wilson JT, Brown RD, Cherek DR, Dailey JW, Hillman B, Jobe PC, Manno BR, Manno JE, Redetzki HM, Stuart JJ (1980) Drug excretion in human breast milk: Principles, pharmacokinetics and projected consequences. Clin Pharmacokinet 5: 1–66Google Scholar
- 5.Liedholm H, Melander A, Bitzén P-O, Helm G, Lönnerholm G, Mattiason I, Nilsson B, Wåhlin-Boll E (1981) Accumulation of atenolol and metoprolol in human breast milk. Eur J Clin Pharmacol 20 (in press)Google Scholar
- 6.Martindale (1978) The extra pharmacopoeia, 27th ed. The Pharmaceutical Press, London, p 201Google Scholar
- 7.Florey K (1974) Analytical profiles of drug subatances, vol 3. Academic Press, New York London, p 27Google Scholar