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European Journal of Clinical Pharmacology

, Volume 24, Issue 6, pp 773–776 | Cite as

A phenylbutazone dose-finding study in rheumatoid arthritis

  • H. A. Bird
  • P. A. Leatham
  • J. R. Lowe
  • W. W. Downie
  • P. D. Fowler
  • V. Wright
Originals

Summary

Different doses of phenylbutazone have been compared in a double blind study on 32 patients with rheumatoid arthritis in order to determine the minimum effective dose. Of 8 different dose levels studied (90 mg, 150 mg, 180 mg, 240 mg, 270 mg, 300 mg, 360 mg and 450 mg/day) the most efficacious was found to be 300 mg/day. Doses below this did not produce full benefit; no further improvement occurs with higher doses. Although 7/32 patients developed adverse reactions there was no relationship between these and the plasma levels of either phenylbutazone or oxyphenbutazone. An attempt was made to distinguish ‘responders’ from ‘non-responders’. We found no relationship between response and plasma levels of phenylbutazone or oxyphenbutazone.

Key words

phenylbutazone rheumatoid arthritis dose oxyphenbutazone side effects 

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References

  1. 1.
    Fjellstrom KE, Goldberg L, Lindren G, Nilsson F (1957) Phenylbutazone in active period of rheumatoid arthritis. Acta Med Scand 320 [Suppl 157]: 1–49Google Scholar
  2. 2.
    Fowler PD (1967) Marrow toxicity and the pyrazoles. Ann Rheumatol Dis 26: 344–345Google Scholar
  3. 3.
    Brooks PM, Walker JJ, Dick WC, Anderson JA, Fowler PD (1975) Phenylbutazone: A clinico-pharmalogical study in rheumatoid arthritis. Br J Clin Pharmacol 2: 437–442Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • H. A. Bird
    • 1
    • 2
  • P. A. Leatham
    • 1
    • 2
  • J. R. Lowe
    • 1
    • 2
  • W. W. Downie
    • 1
    • 2
  • P. D. Fowler
    • 3
  • V. Wright
    • 1
    • 2
  1. 1.Clinical Pharmacology Unit, Royal Bath HospitalHarrogateUnited Kingdom
  2. 2.Rheumatism Research Unit, University Department of Medicine, General Infirmary at LeedsUnited Kingdom
  3. 3.Staffordshire Rheumatology CentreBurslem, Stoke-on-TrentUnited Kingdom

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