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Accidental overdose of pyrimethamine and sulphadoxine for malaria prophylaxis without adverse effects

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References

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    Bergqvist Y, Eriksson M (1985) Simultaneous determination of pyrimethamine and sulphadoxine in human plasma by highperformance liquid chromatography. Trans Roy Soc Trop Med Hyg 79: 279–301

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    Stickney DR, Simmons WS, De Angelis RL, Rundles RW, Nichol CA (1973) Pharmacokinetics of pyrimethamine (PRM) and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DMP) relevant to meningeal leukemia. Proc Amer Ass Cancer Res 14: 52

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Lindberg, A., Bergqvist, Y. & Rombo, L. Accidental overdose of pyrimethamine and sulphadoxine for malaria prophylaxis without adverse effects. Eur J Clin Pharmacol 31, 253–254 (1986). https://doi.org/10.1007/BF00606671

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Key words

  • pyrimethamine
  • malaria
  • sulphadoxine
  • prophylaxis
  • adverse effects
  • overdose