Enteric-coated and uncoated microgranules of acetylsalicylic acid (ASA), labelled with51Cr, were administered orally to six healthy male volunteers in a cross-over study. Gastric emptying was studied using a profile scanning radiation technique. Absorption of ASA was followed by measuring the plasma concentration of salicylate. Gastric emptying both of uncoated and enteric-coated granules varied considerably between individuals, but in most cases was gradual and extended over a period of several hours. The median time until 50% and 90% were emptied from the stomach was 1 and 3–3.5 h, respectively, for both the uncoated and enteric-coated granules. The absorption of ASA from the uncoated granules occurred in parallel with the gastric emptying. However, with the enteric-coated granules, absorption was delayed for about 3 h after gastric emptying. It was concluded that the slow absorption of ASA from enteric-coated granules could be explained partly by gradual gastric emptying and partly by slow dissolution of the ASA granules in the intestine.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Alpsten M, Bogentoft C, Ekenved G, Sölvell L (1979) On the disintegration of hard gelatin capsules in fasting volunteers using a profile scanning technique. J Pharm Pharmacol 31: 480–481
Blythe RH, Grass GM, MacDonnell DR (1959) The formulation and evaluation of enteric coated aspirin tablets. Am J Pharmacol 131: 206–216
Bogentoft C, Carlsson I, Ekenved G, Magnusson A (1978) Influence of food on the absorption of acetylsalicylic acid from enteric-coated dosage forms. Eur J Clin Pharmacol 14: 351–355
Donaldson RM, Barreras RF (1966) Intestinal absorption of trace quantities of chromium. J Lab Clin Med 68: 484–493
Leonards JR, Levy G (1965) Absorption and metabolism of aspirin administered in enteric-coated tablets. J Am Med Assoc 193: 99–104
Merenda SJ, Green DM (1966) X-ray evaluation of tablet disintegration and gastric passage. Pharmacologist 8: 180
Nimmo WS (1976) Drug, diseases and altered gastric emptying. Clin Pharmacokinet 1: 189–203
Sköldborn H, Arvidsson B, Andersson M (1972) A new whole body monitoring laboratory. Acta Radiol (Suppl 313: 233–241
Wagner JG (1971) Enteric coatings. In: Biopharmaceutics and relevant pharmacokinetics. Drug Intelligence Publications, Hamilton Press, Hamilton Illinois, pp 158–165
Wagner JG, Nelson E (1964) Kinetic analysis of blood levels and urinary excretion in the absorptive phase after single dose of drug. J Pharm Sci 53: 1392–1403
About this article
Cite this article
Alpsten, M., Bogentoft, C., Ekenved, G. et al. Gastric emptying and absorption of acetylsalicylic acid administered as enteric-coated micro-granules. Eur J Clin Pharmacol 22, 57 (1982). https://doi.org/10.1007/BF00606426
- acetylsalicylic acid
- gastric emptying
- 51Cr labelling
- gastric scanning