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Archiv für Toxikologie

, Volume 30, Issue 1, pp 51–59 | Cite as

Studies with dichlorvos vapour in dominant lethal mutation tests on mice

  • B. J. Dean
  • E. Thorpe
Toxicology of Dichlorvos

Abstract

Male CF1 mice were exposed to atmospheres containing dichlorvos at concentrations of 30 and 55 μg per litre of air for 16 h, or to 2.1 and 5.8 μg per litre for 23 h daily for 4 weeks. These exposures to dichlorvos produced no mutagenic effects as expressed by increased pre-implantation losses or early foetal deaths in subsequent test matings. No impairment of male fertility was detected following the exposures to dichlorvos vapour.

Key words

Dichlorvos Trimethyl Phosphate Ethyl Methanesulphonate Dominant Letal Mutagenesis Mouse Inhalation 

Zusammenfassung

Männliche CF1-Mäuse wurden 16 Std lang Dichlorvos-konzentrationen von 30 und 55 μg/l in der Atemluft ausgesetzt, oder sie wurden 4 Wochen lang 23 Std am Tag in einer Atmosphäre gehalten, die 2,1 bzw. 5,8 μg/l Dichlorvos enthielt. Bei den nachfolgenden Paarungen während 8 Wochen kam es nicht zu mutagenen Effekten im Sinne eines gesteigerten frühen Fetaltodes oder präimplantativen Verlustes. Die Fertilität der Männchen blieb unbeeinflußt.

Schlüsselwörter

Dichlorvos Trimethylphosphat Äthylmethansulfat dominant letal Mutagenese Maus inhalation 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • B. J. Dean
    • 1
  • E. Thorpe
    • 1
  1. 1.Tunstall LaboratoryShell Research Ltd.SittingbourneEngland

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