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Archiv für Toxikologie

, Volume 30, Issue 1, pp 29–38 | Cite as

Teratological studies with dichlorvos vapour in rabbits and rats

  • E. Thorpe
  • A. B. Wilson
  • K. M. Dix
  • D. Blair
Toxicology of Dichlorvos

Abstract

The teratogenic potential of inhaled dichlorvos vapour for rabbits and rats was investigated on the offspring of primiparous female Dutch rabbits weighing 2 to 3 kg and primiparous female Carworth E strain rats weighing 200 to 300 g. The animals were exposed throughout pregnancy at concentrations of 0.25, 1.25 and 6.25 μg dichlorvos per litre of air. In an additional experiment pregnant rabbits were exposed to concentrations of 2 and 4 μg dichlorvos per litre of air. The results gave no indication that dichlorvos vapour is teratogenic in rabbits or rats even at exposure concentrations resulting in maternal deaths in rabbits, and causing depression of plasma, erythrocyte and brain cholinesterase activities in pregnant animals of both species.

Key words

Dichlorvos Teratology Inhalation Rat Rabbit 

Zusammenfassung

An Kaninchen und Ratten wurde die teratogene Wirkung von inhaliertem Dichlorvos untersucht. Im Versuch waren primipare Kaninchenweibchen der Rasse “Dutch” mit einem Anfangsgewicht von 2 bis 3 kg und primipare Rattenweibchen vom Stamm “Carworth Farm E“ mit einem Anfangsgewicht von 200 bis 300 g. Die Tiere wurden während der gesamten Trächtigkeit folgenden Konzentrationen in der Atemluft ausgesetzt: 0,25, 1,25 und 6,25 μg Dichlorvos pro Liter Luft. Ein zusätzliches Experiment am Kaninchen wurde mit 2 und 4 μg Dichlorvos pro Liter Luft durchgeführt. Die Behandlung wirkte weder beim Kaninchen noch bei der Ratte teratogen. Selbst Konzentrationen, die für die Kaninchen tödlich waren, und die eine deutliche Cholinesterasehemmung in Plasma, Erythrocyten und Gehirn der Ratten und Kaninchen hervorriefen, wurden ohne Schädigung für die Feten vertragen.

Schlüsselwörter

Dichlorvos Teratologie Inhalation Ratte Kaninchen 

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Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • E. Thorpe
    • 1
  • A. B. Wilson
    • 1
  • K. M. Dix
    • 1
  • D. Blair
    • 1
  1. 1.Tunstall LaboratoryShell Research Ltd.SittingbourneEngland

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