A 66-year-old woman with a right hemiplegia due to cerebral haemorrhage was found to have heterotopic grey matter in the left frontal and right frontal and parietal lobes. She had no neurological disturbance prior to the haemorrhage. Regional cerebral blood flow (rCBF) was measured by xenon-CT (Xe-CT) in the zones of heterotopic grey matter during voluntary movement and sensory stimulation of her left limbs. During voluntary movement, rCBF increased markedly in the heterotopic grey matter of the frontal lobes and the overlying cortex. During sensory stimulation, rCBF increased in the right parietal heterotopic grey matter and the overlying cortex. This strongly suggests that the heterotopic grey matter is functional.
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Michael MA, Matter AG (1978) Malformation of the cerebral cortex with heterotopia of the gray matter. J Comput Assist Tomogr 2:291–296
Hager BC, Dyme Z, Guertin SR, Tyler RJ, Tryciecky EW, Fratkin JD (1991) Linear nevus sebaceous syndrome: megalencephaly and heterotopic gray matter. Pediatr Neurol 7:45–49
Zimmerman RA, Bilaniuk LT, Grossman RI (1983) Computed tomography in migratory disorders of human brain development. Neuroradiology 25:257–263
Barkovich AJ, Jackson DE, Boyer RS (1989) Band heterotopias: a newly recognized neuronal migration anomaly. Radiology 171:455–458
Layton DD (1967) Heterotopic cerebral gray matter as an epileptogenic focus. J Neuropathol Exp Neurol 121: 244–249
Zisch R, Artmann W (1991) MRI in the diagnosis of heterotopic gray matter; report of three cases first discovered in adulthood. Neuroradiology 33:527–528
Arena A, Scuderi D (1990) Heterotopic gray matter: report of a case. Ital J Neurol Sci 11:301–302
Mineura K, Fushimi S, Sugawara T, Kowada M (1990) Computed tomography (CT) and magnetic resonance (MR) imaging of heterotopic gray matter presenting with late-onset seizures. Comput Med Imaging Graph 14:217–220
Dunn V, Mock T, Bell WE, Smith W (1986) Detection of heterotopic gray matter in children by magnetic resonance imaging. Magn Reson Imaging 4: 33–39
Deeb ZL, Rothfus WE, Maroon JC (1985) MR imaging of heterotopic gray matter. J Comput Assist Tomogr 9: 1140–1141
Smith AS, Weinstein MA, Quencer RM, et al (1988) Association of heterotopic gray matter with seizures: MR imaging. Radiology 168:195–198
Bairamian D, Chiro GD, Theodore WH, Holmes MD, Dorwart RH, Larson SM (1985) MR imaging and positron emission tomography of cortical heterotopia. J Comput Assist Tomogr 9: 1137–1139
Meyer JS, Shinohara T, Imai A, et al (1988) Imaging local cerebral blood flow by xenon-enhanced computed tomography: technical optimization procedures. Neuroradiology 30:283–292
Henkes H, Hosten N, Cordes M, Neumann K, Hansen ML (1991) Increased rCBF in gray matter heterotopias detected by SPECT using99mTc hexamethyl-propylenamine oxime. Neuroradiology 33:310–312
Gur D, Yonas H, Good WF (1989) Local cerebral blood flow by xenon-enhanced CT: current status, potential improvements, and future directions. Cerebrovasc Brain Metab Rev 1:68–86
Kety S (1951) The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3:1–41
Volpe JJ (1977) Normal and abnormal human brain development. Clin Perinatol 4:3–30
Taylor DC, Falconer MA, Bruton CJ, Corsellis JAN (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369–387
Kernohan JW (1930) Cortical anomalies, ventricular heterotopias and occlusion of the aqueduct of Sylvius. Arch Neurol Psychiatry 23:460–480
Meencke HJ, Janz D (1985) The significance of microdysgenesis in primary generalized epilepsy: an answer to the considerations of Lyon and Gastaut. Epilepsia 26:368–371
Friede RL (1975) Developmental neuropathology. Springer, New York Berlin Heidelberg, pp 1–23, 197–339
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Shimodozono, M., Kawahira, K. & Tanaka, N. Functioning heterotopic grey matter? Increased blood flow with voluntary movement and sensory stimulation. Neuroradiology 37, 440–442 (1995). https://doi.org/10.1007/BF00600084
- Heterotopic grey matter
- Xenon computed tomography
- Regional cerebral blood flow