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The interaction between short-term exercise training and a diuretic-induced hypovolemic stimulus

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Abstract

Nine healthy untrained males [mean (SEM) age, 20.2 (1) years; peak oxygen uptake (VO2max, 48.2 (2) ml · kg−1 · min−1] took part in a study to examine whether short-term exercise training (cycle exercise 2 h · day−1 for 3 days at 60%\(\dot VO_{2max}\)), which normally results in an expansion of plasma volume (PV), can counteract a diuretic-induced hypovolemic stimulus (100 mg triamterene + 50 mg hydrochlorothiazide day−1 for 5 days concurrent with exercise training) and restore PV to control levels. Resting and exercise responses (90 min, 60%\(\dot VO_{2max}\)) in the diuretic plus exercise training condition (D + E) were compared to a control (C) and a diuretic (D) condition in which no exercise was performed. Following the short-term training, PV was still decreased (P < 0.05) below C by −8.3 (3)% in D + E and was similar (P > 0.05) to the reduction in D [−12.4 (2)%]. The reduced PV in response to the diuretic was associated with similar (P > 0.05) elevations in resting aldosterone (ALDO) and norepinephrine (NOREPI) levels (ng · 100 ml−1) in D [101 (12), 61 (4)] and D + E [85 (16), 60 (10)] above (P < 0.05) C [22 (5), 37 (4)]. During exercise, ALDO levels were increased (P < 0.05) by 66 (5) and 70 (10) ng · 100 ml−1 in D and D + E, respectively, and the increase was greater (P < 0.05) than C [44 (8) ng · 100 ml−1]. The rise in NOREPI during exercise was lower (P < 0.05) in D + E [164 (44) ng · 100 ml−1] than in D [244 (24) ng · 100 ml−1] with levels similar to C [176 (25) ng · 100 ml−1]. Thus, the ALDO response to the diuretic was heightened at rest and during exercise but was not additionally affected by the short-term training session. Results suggest that 3 days of exercise training are unable to counteract the hypovolemic effects of a diuretic and restore PV to control levels despite chronic elevations in NOREPI and ALDO.

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Correspondence to D. H. Zappe.

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Zappe, D.H., Helyar, R.G. & Green, H.J. The interaction between short-term exercise training and a diuretic-induced hypovolemic stimulus. Europ. J. Appl. Physiol. 72, 335–340 (1996). https://doi.org/10.1007/BF00599694

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Key words

  • Plasma volume
  • Plasma proteins Fluid-regulating hormones
  • Aldosterone
  • Hydration status