Magnetic resonance imaging and a comprehensive cognitive evaluation were carried out in a series of 29 patients with mild to moderate Huntington's disease (HD). A factor analysis of the neuropsychological test scores provided three factors: a memory/speed-of-processing factor, a “frontal” factor, and a response inhibition factor. The memory/speed factor correlated significantly with measures of caudate atrophy, frontal atrophy, and atrophy of the left (but not the right) sylvian cistern. There were no significant correlations between the “frontal” or response inhibition factors and measures of cortical or subcortical brain atrophy. Our findings confirm that subcortical atrophy is significantly correlated with specific cognitive deficits in HD, and demonstrate that cortical atrophy also has important association with the cognitive deficits of patients with HD.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Folstein SE (1989) Huntington's disease: a disorder of families. The Johns Hopkins University Press, Baltimore
Starkstein SE, Brandt, J, Folstein SE, Strauss M, Berthier ML, Pearlson GD, Wong D, McDonnell A, Folstein M (1988) Neuropsychological and neuroradiological correlates in Huntington's disease. J Neurol Neurosurg Psychiatry 51:1259–1263
Sax D, O'Donnell, B, Butters N, Menzer L, Montgomery K, Kayne L (1983) Computed tomography, neurologic, and neuropsychological correlates of Huntington's disease. J Neurosci 18: 21–36
Bamfort KA, Kido DK, Plassche WM, Shoulson I (1989) Clinicalpathologic correlation in Huntington's disease: a neuropsychological and computed tomography study. Neurology 39: 796–801
Folstein SE, Leigh RJ, Parhad IM, Folstein MF (1986) The diagnosis of Huntington's disease. Neurology 36: 1279–1283
Wechsler D (1955) Wechsler adult intelligence scale manual. Psychological Corporation, New York
Benton AL (1968) Differential behavioral affects in frontal lobe disease. Neuropsychology 6: 53–60
Jones-Gotman M, Milner B (1977) The invention of nonsense drawings after focal cortical lesions. Neuropsychology 15: 653–674
Reitan RM (1958) Validity of the trail making test as an indicator of organic brain damage. Percept Mot Skills 8: 271–276
Morris JC, Heyman A, Mohs RC (1989) The consortium to establish a registry for Alzheimer's disease (CERAD). I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39: 1159–1165
Stuss DT, Benson DF (1986) The frontal lobes. Raven Press, New York
Nelson HE (1976) A modified card sorting test sensitive to frontal lobe defects. Cortex 12: 313–324
Benton AL (1974) The revised visual retention test. 4th edn. The Psychological Corporation, New York
Stroop JR (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18: 643–662
Starkstein SE, Folstein SE, Brandt J, Pearlson GD, McDonnell A, Folstein M (1989) Brain atrophy in Huntington's disease: a CT-scan study. Neuroradiology 31: 156–159
Starkstein SE, Troncoso JC, Hruban R, Kumar A, Robinson RG (1991) Area measurements of the caudate nucleus using magnetic resonance imaging: a validation study. Neuroradiology (In print)
Simmons TJ, Pastakia B, Chase TN, Shults CW (1986) Magnetic resonance imaging in Huntington disease. AJNR 7: 25–28
Berent S, Giordani B, Lehtiner S, Markel D, Penney JB, Buchtel HA, Starosta-Rubinstein S, Hichwa R, Young AB (1988) Positron emission tomographic scan investigations of Huntington's disease: cerebral metabolic correlates of cognitive function. Ann Neurol 23: 541–546
About this article
Cite this article
Starkstein, S.E., Brandt, J., Bylsma, F. et al. Neuropsychological correlates of brain atrophy in Huntington's disease: a magnetic resonance imaging study. Neuroradiology 34, 487–489 (1992). https://doi.org/10.1007/BF00598956
- Huntington's disease
- Magnetic resonance imaging
- Brain atrophy