A questionnaire sent to members of the British Society of Neuroradiologists revealed that the majority of practitioners will, when necessary, inject more than 3 g of iodine during myelography with iohexol or iopamidol. The 3 g limit recommended by the contrast medium manufacturers is not based upon scientific studies involving these media, and it is the experience of British neuroradiologists that larger amounts of modern contrast agents can be used without an increase in post myelography complications. There is, therefore, a need for a controlled trial to assess the question of the most appropriate dose of contrast medium in myelography.
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Arnell S, Lidstrom F (1931) Myelography with skiadan (abrodil). Acta Radiol 12:287
Ahlgren P (1975) Amipaque myelography. The side effects compared with dimer X. Neuroradiology 9:197
Grainger RG, Kendall BE, Wylie IG (1976) Lumbar myelography with metrizamide, a new non ionic contrast medium. Br J Radiol 49:996
Grainger RG (1977) Technique of lumbar myelography with metrizamide. Acta Radiol [Suppl] 335:31–37
Salveson S (1973) Acute toxicity tests of metrizamide. Acta Radiol [Suppl] 335:5–8
Salveson S (1973) Experimental investigations with metrizamide with relevance to myelographic use. Acta Radiol [Suppl] 335:9
Duprey LP, Drobeck HP (1975) Acute intracisternal toxicity of metrizamide in new-born, and young adult rabbits. Internal report at Sterling Winthrop Research Institute, London
Ho KC, Larson SJ, Unger GF, Correa-Paz F (1977) Experimental production of archnoiditis with water soluble contrast media. Radiology 123:681
Aulie A (1980) Effect of iohexol, metrizamide, and ioxaglate on the blood brain barrier. Acta Radiol [Suppl] 362:13
Salveson S (1980) Acute intravenous toxicity of iohexol in the mouse and the rat. Acta Radiol [Suppl] 362:73
Jacobson T (1982) The preclinical development of iohexol. Farmakoterapi 38:45
Simon JH, Ekholm SE, Kido DK, Utz R, Erikson J (1987) High dose iohexol myelography. Radiology 163:455–458
Kendall B (1989) Safety aspects and tolerability of non ionic contrast media-subarachnoid use. Excerpta Medica International Congress Series 816:47–56
Broadbridge AT, Bayliss SG, Brayshaw CI (1987) The effect of intrathecal iohexol on visual evoked response latency: a comparison including incidence of headache with iopamidol and metrizamide in myeloradiculopathy. Clin Radiol 38:71–74
Wilkinson AG, Sellar RJ (1991) The influence of needle size and other factors on the incidence of adverse effects caused by myelography. Clin Radiol (In press)
Maly P, Almen T, Golman K, Olivecrona H (1984) Excitative effects in anaesthetised rabbits from sub arachnoidally injected iso- and hyperosmolar solutions of iohexol and metrizamide. Neuroradiology 26:131–136
Aakhus T, Dahlstrom K, Shaw DD, Leese Ph T, March L (1983) Human Pharmacologic Trials with Iohexol. Acta Radiol [Suppl] 336:20–22
Valk J, Crezee FC, de Slegte RGM, Hazenberg GJ, Wolbers J, Bach-Gansmo T (1987) Iohexol 300 mg I/ml versus iopamidol 300 mg I/ml for cervical myelography: double blind trial. Neuroradiology 29:202–205
Bryan RN, Centeno RS, Hershkowitz P, Poelstra RJ, Osato MS (1982) Neurotoxicity of iohexol, a new non ionic contrast medium. Radiology 145:379–382
Gebarski SS Gabrielsen TO, Knake JE, Latack JT, Yang PJ, Hoff JT (1985) Iohexol versus metrizamide for cervical myelography. AJNR 6:923–926
Latchaw RE, Sackett JF, Turski PA, Shaw DD (1985) Iohexol for cervical myelography via C1−C2 puncture; Study of efficacy and adverse reactions. AJNR 6:927–930
Kendall B, Harrison M, Schneidau A (1983) Clinical trial of iohexol in lumbar myelography. Acta Radiol 24:507–510.
McPherson P, Teasdale E, Coutinho C, McGeroge A (1985) Iohexol versus iopamidol for cervical myelography. Br J Radiol 58: 849–851
Batty VB (1984) Cervical myelography using iohexol, a new contrast medium. Clin Radiol 35:75–77
Kendall B, Stevens J (1984) Cervical myelography with iohexol. Br J Radiol 57:785–787
Nakstad P, Aaserud O, Helgetveit A, Nyberg Hansen R, Ganes T, Bach-Gansmo T (1984) Cervical myelography with iohexol. Neuroradiology 26:123–129
Sant T, Stovner LJ, Dale L, Salveson R (1987) Side effects after diagnostic lumbar puncture and lumbar iohexol myelography. Neuroradiology 29:385–388
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Halpin, S.F.S., Guest, P.J. & Byrne, J.V. Theory and practice: how much contrast for myelography?. Neuroradiology 33, 411–413 (1991). https://doi.org/10.1007/BF00598614
- Contrast medium
- Dose limitation