With the aim of studying the suitability of the 2-cyano group for the protection of carboxylic functions in peptide synthesis, we have obtained the 2-cyanoethyl esters of a number of amino acids and have studied their behavior under the conditions of peptide synthesis. The synthesis of the pentapeptide leucine-enkaphalin has been performed with the use of 2-cyanoethyl protection for C-terminal carboxy groups throughout. The physicochemical characteristics of the compounds synthesized are given.
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Kalashnikov, V.V., Samukov, V.V. Protection of the carboxy group in the form of the 2-cyanoethyl ester in synthesis of peptides. Chem Nat Compd 24, 351–354 (1988). https://doi.org/10.1007/BF00598586
- Organic Chemistry
- Physicochemical Characteristic