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Synthesis of some bis(2-morpholino-1-methylethyl) esters of carboxylic acids and study of their interaction with the cholinesterases of warm-blooded animals

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Abstract

The bis(2-morpholino-1-methylethyl) esters of glutaric, adipic, azelaic, and sebacic acids have been synthesized, and their dihydrochlorides and dimethiodides have been obtained. The structures of the compounds obtained have been shown by their IR and PMR spectra. The interaction of the compounds synthesized with the acetylcholineresterase (ACE) of human blood erythrocytes and the butyrylcholinesterase (BuCE) of horse blood serum have been investigated. All the bis-esters are reversible competitive inhibitors of ACE and BuCE, while the dimethiodides exhibit specificity of their action with respect to ACE.

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Additional information

Institute of Bioorganic Chemistry, Uzbek SSR Academy of Sciences, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 239–243, March–April, 1998.

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Gulyamov, M., Dalimov, D.N., Tilyabaev, Z. et al. Synthesis of some bis(2-morpholino-1-methylethyl) esters of carboxylic acids and study of their interaction with the cholinesterases of warm-blooded animals. Chem Nat Compd 24, 203–206 (1988). https://doi.org/10.1007/BF00596751

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Keywords

  • Ester
  • Organic Chemistry
  • Carboxylic Acid
  • Blood Serum
  • Human Blood