Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

MRI in detection of brain metastases at initial staging of small-cell lung cancer

Abstract

We prospectively investigated 40 patients with small-cell carcinoma of the lung (SCLC) for signs of brain metastasis by neurological examination and MRI of the brain, to determine the significance of MRI for staging. MRI could not be completed in one patient, who was excluded from the study. The MRI studies of the remaining patients showed no abnormalities in 12, cerebral infarcts in 2 and brain metastases in 11 patients, of whom 3 no relevant symptoms. Nonenhancing white matter lesions were found in 14 patients. In 3 of the 4 patients with an abnormal neurological examination at diagnosis, nonenhancing white matter lesions later developed into contrast enhancing lesions compatible with brain metastases; in 2, this occurred during the course of the chemotherapy. MRI did not change the clinical staging in patients with asymptomatic brain metastases.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Viallet J, Ihde DC (1991) Small cell carcinoma of the lung: clinical and biologic aspects. Crit Rev Oncol Hematol 11:109–135

  2. 2.

    Hansen HH (1992) Management of small-cell cancer of the lung. Lancet 339:846–849

  3. 3.

    Pedersen AG (1986) Diagnostic procedures in the detection of CNS metastases from small cell lung cancer. In: Hansen HH (ed) Lung cancer: basic and clinical aspects. Martinus Nijhoff, Boston, pp 153–182

  4. 4.

    Sculier JP, Feld R, Evans WK, et al (1987) Neurologic disorders in patients with small cell lung cancer. Cancer 60: 2275–2283

  5. 5.

    Cruz JM, Jackson DV Jr, Muss HB, Spurr CL, Capizzi RL (1984) Detection of brain metastasis at diagnosis of small cell carcinoma of the lung. J Neurooncol 2:67–71

  6. 6.

    Levitan N, Hong WK, Byrne RE, et al (1984) Role of computerized cranial tomography in the staging of small cell carcinoma of the lung. Cancer Treat Rep 68:1375–1377

  7. 7.

    Johnson DH, Windham WW, Allen JH, Greco FA (1983) Limited value of CT brain scans in the staging of small cell lung cancer. AJR 140:37–40

  8. 8.

    Habets JT, van Ooosterhout AGM, ten Velde GPM, Wilmink JT, Twijnstra A (1992) Diagnostic value of CT in the detection of brain metastasis in small cell lung cancer patients. JBR-BTR 75: 179–181

  9. 9.

    Sze G, Milano E, Johnson C, Heier L (1990) Detection of brain metastases: comparison of contrast-enhanced MR with unenhanced MR and enhanced CT. AJNR 11:785–791

  10. 10.

    Russell EJ, Geremia GK, Johnson CE, et al (1987) Multiple cerebral metastases: detectability with Gd-DTPA-enhanced MR imaging. Radiology 165: 609–617

  11. 11.

    Elster AD, Chen MYM (1992) Can nonenhancing white matter lesions in cancer patients be disregarded? AJNR 13:1309–1315

  12. 12.

    Davis PC, Hudgins PA, Peterman SB, Hoffman JC Jr (1991) Diagnosis of cerebral metastases: double-dose delayed CT vs contrast-enhanced MR imaging. AJNR 12:293–300

  13. 13.

    Yetkin FZ, Haughton VM, Fischer ME, et al (1992) High-signal foci on MR images of the brain: observer variability in their quantification. AJR 159:185–188

  14. 14.

    Fazekas F (1989) Magnetic resonance signal abnormalities in asymptomatic individuals: their incidence and functional correlates. Eur Neurol 29:164–168

  15. 15.

    Fazekas F, Kleinert R, Offenbacher H, et al (1991) The morphologic correlate of incidental punctate white matter hyperintensities on MR images. AJR 157: 1317–1323

Download references

Author information

Correspondence to A. Twijnstra.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

van de Pol, M., van Oosterhout, A.G.M., Wilmink, J.T. et al. MRI in detection of brain metastases at initial staging of small-cell lung cancer. Neuroradiology 38, 207–210 (1996). https://doi.org/10.1007/BF00596529

Download citation

Key words

  • Small-cell lung cancer
  • Brain metastasis
  • Magnetic resonance imaging
  • Staging