Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Diffuse “fibrillary” astrocytomas: correlation of MRI features with histopathologic parameters and tumor grade

  • 105 Accesses

  • 33 Citations


MR images in 54 patients with biopsy-proven diffuse or “fibrillary” astrocytomas were analyzed and compared with the histopathologic features in order to determine which histopathologic characteristics underlie the radiographic findings in these gliomas and whether radiographic findings are more closely correlated with individual histopathologic characteristics than with histologically determined tumor grade. The MRI features studied included tumor heterogeneity, edema, mass effect, border sharpness, “anatomic invasion”, contrast enhancement, hemorrhage, and the presence of flow voids, calcium and cyst formation. The histopathologic characteristics studied included cellular atypia, mitoses, cellularity, endothelial proliferation, necrosis and tumor grade. Edema (P<0.01), flow voids (P=0.02) and contrast enhancement (P<0.01) demonstrated a direct correlation with tumor grade, but edema (P<0.01) and contrast enhancement (P<0.01) also demonstrated a significant correlation to tumor cellularity. Tumor heterogeneity was associated with the presence of necrosis (P=0.01). Hemorrhage occurred only in high grade tumors, where it correlated with endothelial proliferation (P=0.04).

This is a preview of subscription content, log in to check access.


  1. 1.

    Burger PC (1983) Pathologic anatomy and CT correlation in the glioblastoma multiforme. Appl Neurophysiol 46:180–187

  2. 2.

    Daumas-Duport C, Monsaigneon V, Blond S, Munari C, Musolino A, Chodkiewicz JP, Missir O (1987) Serial stereotactic biopsies and CT scan in gliomas: correlative study in 100 astrocytomas, oligoastrocytomas and oligodendrocytomas. J Neuro-Oncol 4:317–328

  3. 3.

    Dean BL, Drayer BP, Bird CR, Flom RA, Hodak JA, Coons SW, Carey RG (1990) Gliomas: classification with MR imaging. Radiology 174:411–415

  4. 4.

    Kelly PJ, Daumas-Duport C, Scheithauer BW, Kall BA, Kispert DB (1987) Stereotactic histologic correlations of computed tomography-and magnetic resonance imaging. Cancer 62:450–459

  5. 5.

    Atlas SW, Tanna NK, Lenkinski RE, et al (1989) Intracerebral gliomas: quantitative imaging with integrated MR imaging, MR spectroscopy, and PET. Proceedings of the Annual Congress of the Radiological Society of North America, Chicago, November 26–December 2, 1989

  6. 6.

    Goerss SJ, Kelly PJ, Kall BA, Alker GJ (1982) A computed tomographic stereotactic adaptation system. Neurosurgery 10: 375–379

  7. 7.

    Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P (1988) Grading of astrocytomas. A simple and reproducible method. Cancer 62:2152–2165

  8. 8.

    Rosner B (1986) Fundamentals of biostatistics, 2nd edn. Duxbury Press, Boston, pp 419–124

  9. 9.

    Ringertz J (1950) Grading of gliomas. Acta Pathol Microbiol Scand 27:51–64

  10. 10.

    Kernohan JW, Mabon RF, Svien HJ, Adson AW (1949) Simplified classification of gliomas. Proc Mayo Clin 24:71–75

  11. 11.

    Zulch KJ (1979) Histologic typing of tumours of the central nervous system. International Histological Classification of Tumours, no 21. WHO, Geneva, pp 17–57

  12. 12.

    Nelson JS, Tsukada Y, Schoenfeld D, et al (1983) Necrosis as a prognosis criteria in malignant supratentorial astrocytic gliomas. Cancer 52:550–564

  13. 13.

    Burger PC, Vogel FS, Green SB, Strike TA (1985) Glioblastoma multiforme and anaplastic astrocytoma: pathologic criteria and prognostic implications. Cancer 56:1106–1111

  14. 14.

    Earnest F, Kelly PJ, Scheithauer BW, Kall BA, Cascino TL, Ehman RL, Forbes GS, Axley PL (1988) Cerebral astrocytomas: histopathologic correlation of MR and CT contrast enhancement with stereotactic biopsy. Radiology 1166:823–827

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tervonen, O., Forbes, G., Scheithauer, B.W. et al. Diffuse “fibrillary” astrocytomas: correlation of MRI features with histopathologic parameters and tumor grade. Neuroradiology 34, 173–178 (1992). https://doi.org/10.1007/BF00596330

Download citation

Key words

  • Magnetic resonance imaging
  • Glioma
  • Tumor histology
  • Tumor grade