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Collagenolytic-like activity of normal human epidermis

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Summary

A protease with a bacterial-like collagenolytic activity was demonstrated in epidermal homogenates of 7 normal human volunteers, using the epidermis of suction-induced blisters and a synthetic chromophore substrate. The enzyme was quantitated and expressed in terms of an equivalent amount of bacterial collagenase.

The relationship of these proteases to the different collagenases is discussed.

Zusammenfassung

Eine Protease mit bakterienähnlicher collagenolytischer Aktivität wurde in Epidermishomogenaten aus Saugblasen von 7 Normalpersonen unter Verwendung eines synthetischen Chromophorensubstrates gefunden.

Die Enzymaktivität wurde quantitativ in Äquivalentmengen zu bakterieller Collagenase bestimmt. Das Verhältnis dieser Protease zu den verschiedenen Collagenasen wird diskutiert.

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Supported by a grant from the Research Committee, Faculties of Medical Sciences, American University of Beirut.

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Kaidbey, K.H., Kurban, A.K. & Tenekjian, K. Collagenolytic-like activity of normal human epidermis. Arch. Derm. Forsch. 242, 1–5 (1971). https://doi.org/10.1007/BF00595284

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Keywords

  • Public Health
  • Enzyme
  • Collagenase
  • Equivalent Amount
  • Human Volunteer