The pressure conditions at the distal end of the interlobular arteries and in the interlobular veins were investigated from the pressures obtained in superficial small arteries and veins, accidentally found on the kidney surface, during the subsequent blockade of the blood stream in the down-stream and up-stream direction, respectively.
The results suggested a hydrostatic pressure in the distal end of the interlobular arteries of about 85 mm Hg under normotensive conditions-a pressure which remained fairly constant when the perfusion pressure in the renal artery was decreased within the autoregulation range. The results indicate a considerable pressure drop of about 40 mm Hg along the interlobular arteries. During hypotension this pressure drop decreased, implying a decreased resistance in the interlobular arteries, i.e.a typical autoregulative response.
The pressure in the interlobular veins amounted to about 5 mm Hg, which is a few mm Hg higher than that in the renal vein and about 7 mm lower than that in the peritubular capillary network. The results suggest a flow resistance located somewhere between the peritubular capillaries and the intrarenal veins. This resistance is not influenced by vasoactive substances but it is decreased when the systemic venous pressure is raised above 10 mm Hg. The resistance seems to act in the direction of protecting the peritubular capillaries from minor changes in the central venous pressure.
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Andreucci, V. E., Dal Canton, A., Corradi, A., Migone, L.: Role of efferent arteriole (EA) in glomerular haemodynamics of superficial nephrons. 6th. Int. Cong. Nephrology, p. 174. Firenze 1975
Brenner, B. M., Troy, J. L., Daugharty, T. M.: Pressures in cortical structures of the rat kidney. Amer. J. Physiol.222, 246–251 (1972)
Fourman, J., Moffat, D. B.: The blood vessels of the kidney. Oxford: Blackwell Scientific Publ. 1971
Frödin, L., Engberg, A., Källskog, Ö., Wolgast, M.: Renal transplantation in the rat. IV. Cortical pressure gradients measured in vivo and during isolated perfusion with reference to renal function after transplantation. Scand. J. clin. Lab. Invest.35, 463–472 (1975)
Gertz, K. H., Mangos, J. A., Braun, G., Pagel, H. D.: Pressure in the glomerular capillaries of the rat kidney and its relation to arterial blood pressure. Pflügers Arch. ges. Physiol.288, 369–374 (1966)
Gottschalk, C. W., Mylle, M.: Micropuncture study of proximal tubules and peritubular capillaries of the rat kidney and their relation to ureteral and renal venous pressures. Amer. J. Physiol.185, 430–439 (1956)
Intaglietta, M., Pawula, R. F., Tompkins, W. R.: Pressure measurements in the mammalian microvasculature. Microvasc. Res.2, 212–220 (1970)
Johnson, P. C.: Review of previous studies and current theories of autoregulation. Circulat. Res. 14–15, 2–9, suppl. I (1964)
Källskog, Ö., Lindbom, L.-O., Ulfendahl, H. R., Wolgast, M.: Regional and single glomerular blood flow in the rat kidney prepared for micropuncture. A methodological study. Acta physiol. scand.94, 145–154 (1975a)
Källskog, Ö., Lindbom, L.-O., Ulfendahl, H. R., Wolgast, M.: The pressure-flow relationship of different nephron populations in the rat. Acta physiol. scand.94, 289–300 (1975b)
Källskog, Ö., Lindbom, L.-O., Ulfendahl, H. R., Wolgast, M.: Kinetics of the glomerular ultrafiltration in rat kidney. An experimental study. Acta physiol. scand.95, 293–300 (1975c)
Källskog, Ö., Wolgast, M.: Driving forces over the peritubular capillary membrane in the rat kidney during antidiuresis and saline expansion. Acta physiol. scand.89, 116–125 (1973)
Lewy, J. E., Windhager, E.: Peritubular control of proximal tubular reabsorption in the rat kidney. Amer. J. Physiol.214, 945–954 (1968)
McNay, J. L., Abe, Y.: Pressure-dependent heterogeneity of renal cortical blood flow in dogs. Circulat. Res.27, 571–587 (1970)
Morkid, L., Ofstad, J.: Diameter of afferent arteriole (AA) and interlobular artery (ILA) measured with microspheres (MS); Sieving effect on microspheres in measurement of blood flow. 6th Int. Cong. Nephrology, p. 6, Firenze 1975
Persson, E., Ågerup, B., Schnermann, J.: The effect of luminal application of colloids on rat proximal tubular net fluid flux. Kidney Int.2, 203–213 (1972)
Robertson, C. R., Deen, W. M., Troy, J. L., Brenner, B. M.: Dynamics of glomerular ultrafiltration in the rat. III. Hemodynamics and autoregulation. Amer. J. Physiol.223, 1191–2000 (1972)
Thurau, K.: Renal hemodynamics. Amer. J. Med.36, 698–719 (1964)
Wiederhielm, C. A., Woodbury, J. W., Kirk, S., Rushmer, R. F.: Pulsatile pressures in the microcirculation of frog's mesentery. Amer. J. Physiol.207, 173–176 (1964)
Wunderlich, P., Persson, E., Schnermann, J., Ulfendahl, H., Wolgast, M.: Hydrostatic pressure in the subcapsular interstitial space of rat and dog kidney. Pflügers Arch.328, 307–319 (1971)
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Källskog, Ö., Lindbom, L.O., Ulfendahl, H.R. et al. Hydrostatic pressures within the vascular structures of the rat kidney. Pflugers Arch. 363, 205–210 (1976). https://doi.org/10.1007/BF00594602
- Rat kidney
- Interlobular arteries
- Intrarenal veins
- Hydrostatic pressures