The 2-site IRMA-design with MCA is demonstrated to be superior over conventional “l-site”-RIA with polyclonal antibodies since it clearly distinguishes different molecular species of a hormone, especially hCG. Such parallel measurements are considered to be of diagnostic value for screening and therapeutic monitoring of tumor patients who produce freeα- and/or freeβ-subunits early in the course of the disease, or exclusively throughout or in addition to holo-hCG.
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Kofler R, Berger P, Wick G (1982) Am J Reprod Immunology 2:212–216
Kofler R, Kalchschmid E, Berger P, Wick G (1981) Immunobiol 160:196–207
Supported by the Austrian Cancer Research Fund 1982/83 and in part by the Österreichische Fonds zur Förderung der wissenschaftlichen Forschung, P.4597, 1983
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Schwarz, S., Berger, P. & Wick, G. Molecular mapping of the immunologic surface of the hCG molecule by monoclonal antibodies (MCA). Z. Anal. Chem. 317, 727 (1984). https://doi.org/10.1007/BF00593881
- Physical Chemistry
- Analytical Chemistry
- Monoclonal Antibody
- Inorganic Chemistry
- Polyclonal Antibody