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The activity of the hypothalamo-hypophysial antidiuretic system in conscious dogs

I. The influence of isoosmotic blood volume changes

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The influence of isoosmotic changes of blood volume on the plasma vasopressin level, osmotic reactivity of the antidiuretic system, arterial blood pressure, central venous pressure and heart rate was examined in 13 conscious intact dogs. The rate of disappearance of exogenous vasopressin under control conditions and during hypovolemia was also investigated. A moderate decrease of blood volume produced a clear cut and persistent increase of the plasma vasopressin level, and a fall of central venous pressure. The same blood loss did not change the rate of disappearance of vasopressin from the plasma.

Moderate blood volume expansion produced a decrease of plasma ADH level and of the osmotic reactivity of the antidiuretic system. Hypervolemia produced a marked increase of central venous pressure and central blood volume.

The result suggest that moderate changes of blood volume modify the activity of the hypothalamo-hypophysial antidiuretic system and support the hypothesis of Gauer and Henry (see [7]) that impulses influencing the activity of the hypothalamo-hypophysial antidiuretic system arise in the central low-pressure part of the circulatory system.

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Szczepańska-Sadowska, E. The activity of the hypothalamo-hypophysial antidiuretic system in conscious dogs. Pflugers Arch. 335, 139–146 (1972). https://doi.org/10.1007/BF00592040

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Key words

  • Vasopressin
  • Hypothalamo-Hypophysial Antidiuretic System
  • Blood Volume