Evidence for phosphate as a mediator of functional hyperaemia in skeletal muscles
Article Received: 13 December 1976 Summary
Maximal twitch contractions of fast muscles of the cat caused an increase in phosphate concentration in the venous plasma from them: this efflux was greater as the contraction frequency was increased. At any given frequency of contraction, the phosphate efflux from contracting gastrocnemius was less than that from tibialis anterior and extensor digitorum longus, which have a higher proportion of fast fibres and exhibit greater functional hyperaemia. Soleus muscles, when contracting, released hardly any additional phosphate, except in the one experiment in which the muscle exhibited a functional hyperaemia. There was thus a consistent relationship between the extent of functional hyperaemia and phosphate efflux in different muscles and within any one group of muscles.
Inorganic phosphate, given close arterially as NaH
2PO 4, was shown to be vasodilator. NaH 2PO 4 was much more potent than Na 2HPO 4, though this did not seem due simply to the associated change of pH. The functional hyperaemia of fast muscles could be matched, qualitatively and quantitatively, by injections or infusions of NaH 2PO 4.
The possibility is discussed that the contraction hyperaemia of fast muscles is functionally related to phosphate release into the interstitial fluid during contractions.
Key words Contraction hyperaemia Inorganic phosphate Muscle blood flow Muscle contraction References
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