Human Genetics

, Volume 75, Issue 2, pp 123–128 | Cite as

Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis

  • Alison M. Goate
  • David N. Cooper
  • Christine Hall
  • Thomas K. C. Leung
  • Ellen Solomon
  • Louis Lim
Original Investigations
Received:

Summary

The human 70 kdalton heat-shock protein (HSP 70) is a member of a multigene family which is expressed in response to various physiological stresses including elevated temperatures. Using a cloned genomic HSP 70 DNA sequence we demonstrate by somatic cell hybrid and restriction fragment length polymorphism (RFLP) analyses that there are a minimum of three distinct HSP 70 loci in the human genome, one of which is located on chromosome 6.

Keywords

Internal Medicine Gene Sequence Elevated Temperature Metabolic Disease Human Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • Alison M. Goate
    • 1
  • David N. Cooper
    • 1
  • Christine Hall
    • 1
  • Thomas K. C. Leung
    • 1
  • Ellen Solomon
    • 2
  • Louis Lim
    • 1
  1. 1.Neurochemistry Department, Institute of NeurologyUniversity of LondonLondonUK
  2. 2.The Imperial Cancer Research FundLincoln's Inn FieldsLondonUK

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