Psychopharmacology

, Volume 99, Issue 4, pp 537–541

Cocaine enhances memory storage in mice

  • Ines B. Introini-Collison
  • James L. McGaugh
Original Investigations

Abstract

Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03–1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on retention was time-dependent: retention latencies were not altered in animals given cocaine 60 min after training. Administration of cocaine (0.1 mg/kg) prior to the retention test did not modify the retention performance of mice that received either saline or cocaine (0.1 mg/kg) immediately post-training. The findings suggest that cocaine affects retention by influencing post-training processes involved in memory storage.

Key words

Cocaine Memory State-dependency Cocaine and reward Catecholamines 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ahlenius S, Engel J (1971) Behavioral effects of haloperidol after tyrosine hydroxylase inhibition. Eur J Pharmacol 15:187–192Google Scholar
  2. Baratti CM, Introini IB, Huygens P (1984) Possible interaction between central cholinergic muscarinic and opioid peptidergic systems during memory consolidation in mice. Behav Neural Biol 40:155–169Google Scholar
  3. Barnerjee S, Sharma VK, Kung-Cheung LS, Chanda SK, Riggi SK (1979) Cocaine andd-amphetamine induce changes in central β-adrenoceptor sensitivity: effects of acute and chronic drug treatment. Brain Res 175:119–130Google Scholar
  4. Castellano C (1974) Cocaine, pemoline and amphetamine on learning and retention of a discrimination test in mice. Psychopharmacologia 36:67–76Google Scholar
  5. D'Mello GD, Goldberg DM, Goldberg SR, Stolerman IP (1979) Conditioned taste aversion and operant behaviour in rats: effects of cocaine and a cocaine analogue (WIN 35,428). Neuropharmacology 18:1009–1010Google Scholar
  6. Fernandez-Tome MP, Sanchez-Blazquez P, del Rio J (1979) Impairment by apomorphine of one-trial passive avoidance learning in mice: the opposing roles of the dopamine and noradrenaline systems. Psychopharmacology 61:43Google Scholar
  7. Flood JF, Cherkin A (1987) Fluoxetine enhances memory processing in mice. Psychopharmacology 93:36–43Google Scholar
  8. Gold PE (1986) Glucose modulation of memory storage. Behav Neurol Biol 45:342–349Google Scholar
  9. Gold PE, van Buskirk R (1978) Posttraining brain norepinephrine concentrations: correlation with retention performance of avoidance training with peripheral epinephrine modulation of memory processing. Behav Biol 23:509–520Google Scholar
  10. Gold PE, McGaugh JL (1975) A single-trace, two-process view of memory storage processes. In: Deutsch D, Deutsch JA (eds) Short-term memory. Academic Press, New York, pp 355–378Google Scholar
  11. Gold PE, Zornetzer SF (1983) The mnemon and its juices: neuromodulation of memory processes. Behav Neural Biol 38:151–189Google Scholar
  12. Gorelick DA, Bozewiez TR, Bridger WH (1975) The role of catecholamines in animal learning and memory. In: Friedhoff AJ (ed) Catecholamines and behavior. Plenum Press, New York, pp 1–30Google Scholar
  13. Holdefer RN, Jensen RA (1987) The effects of peripherald-amphetamine, 4-OH amphetamine, and epinephrine on maintained discharge in the locus coeruleus with reference to the modulation of learning and memory by these substances. Brain Res 417:108–117Google Scholar
  14. Introini-Collison IB, Baratti CM (1986) Opioid peptidergic systems modulate the activity of β-adrenergic mechanisms during memory consolidation processes. Behav Neural Biol 46:227–241Google Scholar
  15. Introini-Collison IB, McGaugh JL (1986) Epinephrine modulates long-term retention of an aversively-motivated discrimination task. Behav Biol 45:358–365Google Scholar
  16. Introini-Collison IB, McGaugh JL (1987) Naloxone and β-endorphin alter the effects of posttraining epinephrine on retention of an inhibitory avoidance response. Psychopharmacology 92:229–235Google Scholar
  17. Introini-Collison IB, Nagahara AH, McGaugh JL (1989) Memory-enhancement with intra-amygdala posttraining naloxone is blocked by concurrent administration of propranolol. Brain Res 476:94–101Google Scholar
  18. Izquierdo I (1980) Effects of a low and a high dose of β-endorphin on acquisition and retention in the rat. Behav Neural Biol 30:460–464Google Scholar
  19. Izquierdo I (1982) β-endorphin and forgetting. TIPS 3:455–457Google Scholar
  20. Izquierdo I, Dias RD (1984) Involvement of α-adrenergic receptors in the amnestic and anti-amnestic actions of epinephrine and ACTH. Psychoneuroendocrinology 9:77–81Google Scholar
  21. Izquierdo I, Dias RD (1985) Influence on memory of posttraining or pretest injections of ACTH, vasopressin, epinephrine, or β-endorphin, and their interaction with naloxone. Psychoneuroendocrinology 10:165–172Google Scholar
  22. Jackson DM, Ahlenius S, Anden NE, Engel J (1977) Antagonism by locally applied dopamine into the nucleus accumbens or the corpus striatum of α-methyltyrosine-induced disruption of conditioned avoidance behavior. J Neural Transm 41:231–239Google Scholar
  23. Kim HJ, Routtenberg A (1976) Retention deficit following posttrial dopamine injection into rat neostriatum. Neurosci Abstr 2:445Google Scholar
  24. Krivanek J, McGaugh JL (1969) Facilitating effects of pre- and posttrial amphetamine administration on discrimination learning in mice. Agents Actions 1:36–42Google Scholar
  25. McGaugh JL (1973) Drug facilitation of learning and memory. Annu Rev Pharmacol 13:229–241Google Scholar
  26. McGaugh JL (1975) Biological bases of memory storage processes: the state of the art. In: Nazzaro JR (ed) Master lectures on physiological psychology, (tape series). NY Am Psychol AssocGoogle Scholar
  27. McGaugh JL (1989) Involvement of hormonal and neuromodulatory systems in the regulation of memory starage. Annu Rev Neurosci 12:255–287Google Scholar
  28. McGaugh JL, Introini-Collison IB, Nagahara AH (1988) Memory-enhancing effects of posttraining naloxone: involvement of β-noradrenergic influences in the amygdaloid complex. Brain Res 446:37–49Google Scholar
  29. Morency MA, Beninger RJ (1986) Dopaminergic substrates of cocaine-induced place conditioning. Brain Res 399:33–41Google Scholar
  30. Oei TPS, King MG (1980) Catecholamines and aversive learning: a review. Neurosci Behav 4:161–173Google Scholar
  31. Oscos A, Martinez JL Jr, McGaugh JL (1988) Effects of posttrainingd-amphetamine on acquisition of an appetitive autoshaped lever press response in rats. Psychopharmacology 95:132–134Google Scholar
  32. Pitts DK, Marwah J (1986) Electrophysiological effects of cocaine on central monoaminergic neurons. Eur J Pharmacol 131:95–98Google Scholar
  33. Pitts DK, Marwah J (1987) Neuropharmacology of cocaine: role of monoaminergic systems. Monogr Neural Sci 13:34–54Google Scholar
  34. Post RM, Kopanda RT, Black KE (1976) Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: relationship of kindling and psychosis. Biol Psychiatry 11:403–419Google Scholar
  35. Ritchie JM, Greene NM (1985) Local anesthetics. In: Goodman Gilman A, Goodman LS, Rall TW, Murad F (eds) Goodman Gilman's The pharmacological basis of therapeutics. MacMillan, New York, pp 302–321Google Scholar
  36. Routtenberg A, Kim HJ (1978) The substantia nigra and neostriatum: substrates for memory consolidation. In: Butcher LL (ed) Cholinergic-monoaminergic interactions in the brain. Academic Press, New York, pp 305–331Google Scholar
  37. Schenk S, Hunt T, Malovechko R, Robertson A, Klukowski G, Amit Z (1986) Differential effects of isolation housing on the conditioned place preference produced by cocaine and amphetamine. Pharmacol Biochem Behav 24:1793–1796Google Scholar
  38. Spyraki C, Fibiger HC, Phillips AG (1982a) Cocaine-induced place preference conditioning: lack of effects of neuroleptics and 6-hydroxydopamine lesions. Brain Res 253:195–203Google Scholar
  39. Spyraki C, Fibiger HC, Phillips AG (1982b) Attenuation by haloperidol of place preference conditioning using food reinforcement. Psychopharmacology 77:379–382Google Scholar
  40. Spyraki C, Nomikos GG, Varonos DD (1987) Intravenous cocaine-induced place preference: attenuation by haloperidol. Behav Brain Res 26:57–62Google Scholar
  41. Sternberg DB, Korol D, Novack G, McGaugh JL (1986) Epinephrine-induced memory facilitation: attenuation by adrenergic receptor antagonists. Eur J Pharmacol 129:189–193Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Ines B. Introini-Collison
    • 1
  • James L. McGaugh
    • 1
    • 2
  1. 1.Center for the Neurobiology of Learning and MemoryUniversity of CaliforniaIrvineUSA
  2. 2.Department of PychobiologyUniversity of CaliforniaIrvineUSA

Personalised recommendations