, Volume 99, Issue 4, pp 537–541 | Cite as

Cocaine enhances memory storage in mice

  • Ines B. Introini-Collison
  • James L. McGaugh
Original Investigations


Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03–1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on retention was time-dependent: retention latencies were not altered in animals given cocaine 60 min after training. Administration of cocaine (0.1 mg/kg) prior to the retention test did not modify the retention performance of mice that received either saline or cocaine (0.1 mg/kg) immediately post-training. The findings suggest that cocaine affects retention by influencing post-training processes involved in memory storage.

Key words

Cocaine Memory State-dependency Cocaine and reward Catecholamines 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Ines B. Introini-Collison
    • 1
  • James L. McGaugh
    • 1
    • 2
  1. 1.Center for the Neurobiology of Learning and MemoryUniversity of CaliforniaIrvineUSA
  2. 2.Department of PychobiologyUniversity of CaliforniaIrvineUSA

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