Psychopharmacology

, Volume 99, Issue 4, pp 486–491

Effect of instructions and nicotine on smoking cessation, withdrawal symptoms and self-administration of nicotine gum

  • John R. Hughes
  • Suzy B. Gulliver
  • Geri Amori
  • Gina C. Mireanlt
  • James F. Fenwick
Original Investigations

DOI: 10.1007/BF00589896

Cite this article as:
Hughes, J.R., Gulliver, S.B., Amori, G. et al. Psychopharmacology (1989) 99: 486. doi:10.1007/BF00589896

Abstract

Seventy-seven smokers quit smoking and were randomly assigned to a 3×2 design contrasting instructions (told received nicotine gum versus told received placebo gum versus not told which gum received) and receipt of nicotine (received nicotine gum versus received placebo gum). Both being told one received nicotine and actual recept of nicotine increased the number of days abstinent and decreased the number of cigarettes smoked (P<0.05). Receipt of nicotine but not instructions appeared to influence withdrawal (P=0.06). Instructions but not recept of nicotine appeared to influence craving (P=0.08), gum selfadministration (P=0.06) and reported helpfulness of the gum (P=0.02). Neither nicotine nor instructions influenced side-effects. Instructions and nicotine interacted in several ways. For example, nicotine appeared to increase abstinence in the blind and told placebo conditions more than in the told nicotine condition (P<0.05). Our results suggest the effects of instructions and nicotine 1) are not mutually exclusive, 2) vary across dependent variables and 3) can interact such that instructions modify the therapeutic and subjective effects of nicotine.

Key words

Blindness Expectancy Nicotine gum Reinforcement Smoking cessation Tobacce withdrawal 

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • John R. Hughes
    • 1
  • Suzy B. Gulliver
    • 1
  • Geri Amori
    • 1
  • Gina C. Mireanlt
    • 1
  • James F. Fenwick
    • 1
  1. 1.Human Behavioral Pharmacology Laboratory, Departments of Psychiatry and PsychologyUniversity of VermontBurlingtonUSA

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