Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Effects on rats of CSF from sleep-deprived rabbits

  • 27 Accesses

  • 8 Citations

Summary

Rabbits were sleep-deprived for 72 hours in revolving drum sleep deprivation cages. Cerebrospinal fluid samples obtained from these sleep-deprived and from control rabbits were infused intraventricularly into rats to assay for the presence of a sleep-promoting material in the sleep-deprived rabbit CSF. Effects on ECoG patterns, ambulatory activity and behavior of the assay rats failed to show sleep-promoting properties for the CSF from sleep-deprived rabbits.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Bell, F. R.: Electroencephalogram of goats during somnolence and rumination. Anim. Behav.8, 39–42 (1960).

  2. 2.

    Goodrich, C. A.: Functional Aspects of Cerebral Extracellular Fluids as Studied in the Rat. Doctoral Thesis, Harvard University 1967.

  3. 3.

    Herndon, B. L., andD. A. Ringle: Methods for neurological experimentation in the mongolian gerbil, Meriones unguiculatus. Lab. Anim. Care (in press).

  4. 4.

    Kornmüller, A. E., H. D. Lux, K. Winkel u.M. Klee: Neurohumoral ausgelöste Schlafzustande an Tieren mit gekreuztem Kreislauf unter der Kontrolle von EEG-Ableitungen. Naturwissenschaften48, 503–505 (1961).

  5. 5.

    Legendre, R., etH. Piéron: Recherches sur le besoin de sommeil consécutif à une vielle prolongée. Z. allg. Physiol.14, 235–262 (1913).

  6. 6.

    Monnier, M., andL. Hösli: Humoral transmission of sleep and wakefulness. II. Hemodialysis of sleep inducing humor during stimulation of the thalamic somnogenic area. Pflügers Arch. ges. Physiol.282, 60–75 (1965).

  7. 7.

    —,Th. Koller, andS. Graber: Humoral influences of induced sleep and arousal upon electrical brain activity of animals with crossed circulation. Exp. Neurol.8, 264–277 (1963).

  8. 8.

    Pappenheimer, J. R., T. B. Miller, andC. A. Goodrich: Sleep-promoting effects of cerebrospinal fluid from sleep-deprived goats. Proc. nat. Acad. Sci. (Wash.)58, 543–547 (1967).

  9. 9.

    Ringle, D. A., andB. L. Herndon: Plasma dialysates from sleep-deprived rabbits and their effect on the electrocorticogram of rats. Pflügers Arch.303, 344–349 (1968).

  10. 10.

    Ruckebusch, Y.: Activité corticale au cours du sommeil chez la chèvre. C. R. Soc. Biol. (Paris)156, 867–870 (1962).

  11. 11.

    Schnedorf, J. G., andA. C. Ivy: An examination of the hypnotoxin theory of sleep. Amer. J. Physiol.125, 491–505 (1939).

  12. 12.

    Schneiderman, N., M. Monnier, andL. Hösli: Humoral transmission of sleep. IV. Cerebral and visceral effects of sleep dialysate. Pflügers Arch. ges. Physiol.288, 65–80 (1966).

  13. 13.

    Snedecor, G. W.: Statistical Methods. Ames, Iowa, Iowa State College Press 1946.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ringle, D.A., Herndon, B.L. Effects on rats of CSF from sleep-deprived rabbits. Pflugers Arch. 306, 320–328 (1969). https://doi.org/10.1007/BF00589157

Download citation

Key-Words

  • Sleep
  • Sleep Deprivation
  • Cerebrospinal Fluid
  • ECoG Recording
  • Ambulatory Activity

Schlüsselwörter

  • Schlaf
  • Schlafberaubung
  • Cerebrospinalflüssigkeit
  • Elektrocorticogramm
  • Ambulante Bewegungen