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Sodium excretion in goldblatt hypertension

Long-term separate kidney function studies in rats by means of a new technique

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Summary

Separate kidney function with special attention to sodium excretion was studied during 18 days in hypertensive rats with unilaterally constricted renal artery. For urine collection the bladder was divided into two separate chambers and drained by a new simple technique. Urinary flow rate of the untouched kidney was always elevated as compared to the clamped kidney. However the clearance of PAH and inulin of the untouched kidney was higher than that of the clamped kidney only during the first postoperative days and during saline intake. The osmolality and the inulin and potassium concentration were usually higher in the urine from the clamped kidney, whereas sodium concentration was higher in the urine from the contralateral kidney. Sodium excretion of the untouched kidney was not only greater than that of the clamped kidney but even greater than that of a normotensive control kidney. On the other hand sodium excretion of the clamped kidney was less than that of a normal kidney. Thus, total renal sodium output of the hypertensive and the normotensive rats did not differ. The reduced sodium excretion of the clamped kidney is interpreted as a consequence of the “exaggerated” sodium excretion of the untouched kidney, which is exposed to the high blood pressure.

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Supported by the Deutsche Forschungsgemeinschaft im Rahmen des SFB 89 Kardiologie Göttingen.

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Kramer, P., Ochwadt, B. Sodium excretion in goldblatt hypertension. Pflugers Arch. 332, 332–345 (1972). https://doi.org/10.1007/BF00588579

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Key words

  • Sodium
  • Water Electrolyte Regulation
  • Renal Artery Obstruction
  • Renal Hypertension