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Activation by ADP and the correlation between tension and ATPase activity in insect fibrillar muscle

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Summary

The effect of ADP on the tension and ATPase activity of glycerinated fibres of the flight muscles of the giant water bugLethocerus cordofanus has been investigated. Both increased, by a variable amount, when the ADP concentration was raised to 1 mM, but the increase was reversed when the concentration was raised further. In another series of experiments, the effect of temperature on the ATPase activity and tension was measured. There was a positive correlation between ATPase activity and tension in both types of experiment, the slopes being similar to those reported by other workers when calcium ion concentration or mean muscle length were altered. The positive feedback resulting from the increase of ATPase activity caused by ADP explains at least in part the variability of the results, and provides a possible explanation of the “high tension state” in glycerinated fibrillar muscle.

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Abbott, R.H., Mannherz, H.G. Activation by ADP and the correlation between tension and ATPase activity in insect fibrillar muscle. Pflugers Arch. 321, 223–232 (1970). https://doi.org/10.1007/BF00588443

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Key-Words

  • Muscle Contraction
  • Adenosine Triphosphatase
  • Adenosine Diphosphate
  • Temperature
  • Glycerol Extracted Insect Muscle

Schlüsselwörter

  • Muskelkontraktion
  • Adenosinetriphosphatase
  • Adenosine-diphosphat
  • Temperatur
  • Glycerolextrahierter Insektmuskel