, Volume 37, Issue 4, pp 331–333 | Cite as

Mineralizing microangiopathy: CT and MRI

  • D. J. Shanley
Paediatric Neuroradiology


Mineralizing microangiopathy, a distinctive histopathologic process involving the microvasculature of the central nervous system (CNS), is usually seen following combined radiation and chemotherapy for the treatment of CNS neoplasms in childhood. CT typically demonstrates calcification within the basal ganglia and subcortical white matter. The areas of calcification may give paradoxically increased signal on T1-weighted MRI due to a surface-relaxation mechanism, and decreased signal on T2-weighted images.

Key words

Mineralizing microangiopathy Chemotherapy R Radiotherapy Computed tomography Magnetic resonance imaging 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Priee RA, Birdwell DA (1978) The central nervous system in childhood leukemia. Cancer 42: 717–728Google Scholar
  2. 2.
    Peylan-Ramu N, Poplack DG, Pizzo PA, et al (1978) Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy. N Engl J Med 298: 815–818Google Scholar
  3. 3.
    Flament-Durand J, Ketelbant-Balasse P, Maurus R, et al (1975) Intracerebral calcifications appearing during the course of acute lymphocytic leukemia treated with methotrexate and x rays. Cancer 35: 319–325Google Scholar
  4. 4.
    Henkelman RM, Watts JF, Kucharczyk W (1991) High signal intensity in MR images of calcified brain tissue. Radiology 179: 199–206Google Scholar
  5. 5.
    Valk PE, Dillon WP (1991) Radiation injury of the brain. AJNR 156: 689–706Google Scholar
  6. 6.
    Kramer S, Lee KF (1974) Complications of radiation therapy: the central nervous system. Semin Roentgenol 9: 75–83Google Scholar
  7. 7.
    Ebner F, Ranner G, Slavc I, et al (1989) MR findings in methotrexate induced CNS abnormalities. AJR 153: 1283–1288Google Scholar
  8. 8.
    Ball WS, Prenger EC, Ballard ET (1992) Neurotoxicity of radio/chemotherapy in children: pathologic and MR correlation. AJNR 13: 761–766Google Scholar
  9. 9.
    Kim EE, Chung S, Haynie TP, et al (1992) Differentiation of residual or recurrent tumors from posttreatment changes with F-18 FDG PET. Radiographics 12: 269–279Google Scholar
  10. 10.
    Segebarth CM, Baleriaux DF, Arnold DL, et al (1987) MR image-guided P-31 MR spectroscopy in the evaluation of brain tumor treatment. Radiology 165: 215–219Google Scholar
  11. 11.
    Ogawa T, Kanno I, Shishido F, et al (1991) Clnical value of PET with18F-fluorodeoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury. Acta Radiol 32: 197–202Google Scholar
  12. 12.
    Kramer JH, Norman D, Brant-Zawadzki M, et al (1988) Absence of white matter changes on magnetic resonance imaging in children treated with CNS prophylaxis therapy for leukemia. Cancer 61: 928–930Google Scholar
  13. 13.
    Aoki S, Okada Y, Nishimura K, et al (1989) Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T. Radiology 172: 381–385Google Scholar
  14. 14.
    Drayer BP (1988) Imaging of the aging brain. Radiology 166: 785–796Google Scholar
  15. 15.
    Cohen CR, Duchesneau PM, Weinstein MA (1980) Calcification of the basal ganglia as visualized by computed tomography. Radiology 134: 97–99Google Scholar
  16. 16.
    Ho VB, Fitz CR, Chuang SH, et al (1993) Bilateral basal ganglia lesions: pediatric differential considerations. Radiographics 13: 269–292Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • D. J. Shanley
    • 1
  1. 1.Department of RadiologyTripler Army Medical CenterHonoluluUSA

Personalised recommendations