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Imaging of human T-lymphotropic virus type I-associated chronic progressive myeloneuropathies

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Summary

We studied magnetic resonance imaging (MRI) of the head and cervical spine and CT of the head in 46 patients (14 men, 32 women) with chronic progressive mycloneuropathy. The findings were correlated with human T-lymphotropic virus type I (HTLV-I) serology, race, country of origin, and age. We found a female predominance of 2∶1. Most patients were aged between 30 and 50 years, and most were Caribbean immigrants and black. There were 9 men and 17 women with blood antibody titers to HTLV-I and 7 men and 15 women with cerebrospinal fluid (CSF) titers. All patients with virus or antibodies in blood or CSF were Caribbean immigrants or black. T2-weighted cranial MRI showed scattered areas of high signal intensity in the cerebral white matter, usually in the periventricular and subcortical areas, but not in the posterior cranial fossa. Cranial CT revealed periventricular low density areas, ventricular enlargement, and atrophy MRI of the cervical spine showed atrophy of the cord. Myelography was normal in all 15 patients examined. No imaging differences were observed between the HTLV-I-positive and-negative patients. These findings, although consistent with demyelination, are not specific.

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References

  1. 1.

    Roman GC, Vernant JC, Osame M (1989) HTLV-I and the nervous system. Neurology and neurobiology, vol 51. Liss, New York

  2. 2.

    Sever JL, Gibbs CLJV (1987) Retroviruses in the nervous system. Little Brown, Boston

  3. 3.

    Vernant JC, Maurs L, Gessain A, Barin F, Gout O, Delaporte JM, Sanhadji K, Buisson G, deThe G (1987) Endemic tropical spastic paraparesis associated with human T-lymphotropic virus type I: a clinical and seroepidemiological study of 25 cases. Ann Neurol 21: 123–130

  4. 4.

    Gessain A, Barin F, Vernant JC, Gout O, Maurs L, Calender A, deThe G (1985) Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet II: 407–410

  5. 5.

    Osame M, Matsumoto M, Usuku K, Izumo S, Ijichi N, Amitani H, Tara M, Igata A (1987) Chronic myelopathy associated with elevated antibodies to human T-lymphotropic virus Type I and adult T-cell leukemia-like cells. Ann Neurol 21: 117–122

  6. 6.

    Morgan OS, Montgomery RD, Rodgers-Johnson P (1988) The myeloneuropathies of Jamaica: an unfolding story. Q J Med 67: 273–281

  7. 7.

    Roman GC (1987) Retrovirus-associated myelopathies. Arch Neurol 44: 659–663

  8. 8.

    Bucher B, Poupard JA, Vernant JC, DeFreitas EC (1990) Tropical neuromyelopathies and retroviruses: a review. Rev Infect Dis 12: 890–899

  9. 9.

    Kennedy PGE (1989) Human immunodeficiency virus infection of the nervous system. Curr Opin Neurol Neurosurg 2: 191–194

  10. 10.

    Valderrama R, Madrid R, Montesinos C, Merino R, Pipia PA (1989) Chronic progressive myeloneuropathies in an immigrant population in New York. In: Roman GC, Vernant JC, Osame M (eds) HTLV-I and the nervous system. Neurology and neurobiology, vol 51. Liss, New York, pp 185–194

  11. 11.

    Osame M, Usuku K, Izumo S, Ijichi N, Amitani H, Igata A, Matsumoto M, Tara M (1986) HTLV-I associated myelopathy: a new clinical entity. Lancet I: 1031–1032

  12. 12.

    Clark JW, Saxinger C, Gibbs WN (1985) Seroepidemiologic studies of human T-cell leukemia/lymphoma virus type I in Jamaica. Int J Cancer 36: 37–41

  13. 13.

    Rodgers-Johnson, Gajdusek DC, Morgan OS, Zaninovic V, Sarin PS, Graham DS (1985) HTLV-I and HTLV-III antibodies and tropical spastic paraparesis. Lancet II: 1247–1248

  14. 14.

    Zaninovic V, Biojo R, Barreto P (1981) Paraparesis espastica del Pacifico. Colombia Med 12: 111–117

  15. 15.

    Kelly R, DeMole H (1982) Paraplegia in the islands of the Indian Ocean. Afr J Neurol Sci 1: 5–7

  16. 16.

    Steiner I, Feir G, Soffer D, Pleet AB, Abramson O (1988) Chronic progressive myelopathy: its relation to the spinal progressive form of multiple sclerosis. Acta Neurol Scand 77: 152–157

  17. 17.

    Roman GC, Roman LN, Spencer PS, Schoenberg BS (1985) Tropical myeloneuropathies: the hidden endemias. Neurology 35: 1158–1170

  18. 18.

    Rosenberg GA, Kornfeld M, Stovring J, Bicknell JM (1979) Subcortical arteriosclerotic encephalopathy (Binswanger): computerized tomography. Neurology 29: 1102–1106

  19. 19.

    Leifer D, Buonanno FS, Richardson PE (1990) Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter. Neurology 40: 911–918

  20. 20.

    Brew BJ, Price RW (1988) Another retroviral disease of the nervous system. N Engl J Med 318: 1195–1197

  21. 21.

    Uhlenbrock D, Schlen S (1989) The value of T1-weighted images in the diffentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE). Neuroradiology 31: 203–212

  22. 22.

    Feasby TE, Hahn AF, Koopman WJ, Lee DH (1990) Central lesions in chronic inflammatory demyelinating polyneuropathy: an MRI study. Neurology 40: 476–478

  23. 23.

    Miska RM, Pojunas KW, McQuillen MP (1987) Cranial magnetic resonance imaging in the evaluation of myelopathy of undetermined etiology. Neurology 37: 840–843

  24. 24.

    Miller DH, McDonald WI, Blumhardt LD, du Boulay GH, Halliday AM, Johnson G, Kendall BE, Kingsley DPE, MacManus DG, Moseley IF, Sandercock PAG (1987) Magnetic resonance imaging in isolated noncompressive spinal cord syndromes. Ann Neurol 22: 714–723

  25. 25.

    Koopmans RA, Li DKB, Grochowski E, Paty DW (1989) Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features. Ann Neurol 25: 74–81

  26. 26.

    McDonald WI, Barnes D (1990) Lessons from magnetic resonance imaging in multiple sclerosis. Trends Neurol Sci 12:376–379

  27. 27.

    Canavaggio M, Leckie G, Allain JW, Steaffens JW, Laurian Y Brettler D, Lee H (1990) The prevalence of antibody to HTLV-I/II in United States plasma donors and in United States and French hemophiliacs. Transfusion 30: 780–782

  28. 28.

    Kira J, Koyanagi Y, Itoyama Y, Yamamoto N, Sasaki H, Sasaki Y (1991) Increased HTLV-I proviral DNA in HILV-I-associated myelopathy: a quantitative polymerase chain reaction study. Ann Neurol 29:194–201

  29. 29.

    Levine PH, Blattner WA (1987) The epidemiology of diseases associated with HTLV-I and HTLV-II. Infect Dis Clin North Am 1: 501–510

  30. 30.

    Bhigjee AI, Kelbe C, Haribhai HC, Windsor IM, Hoffmann MH, Modi G, Bill PLA, Becker WB, Singh B, Engelbrecht S (1990) Myelopathy associated with human T-cell lymphotropic virus type I (HTLV-I) in Natal, South Africa. Brain 113: 1307–1320

  31. 31.

    Thyss A, Michiels JF, Ayela P, Lagrange M, Hoffman P, Schneider M (1990) Leukemia/lymphoma T syndrome associated with HTLV-I in a patient of Moroccan origin. Presse Med 19: 135

  32. 32.

    Power C, Weinshenker BG, Dekaban GA, Ebers GC, Francis GS, Rice GP (1989) HTLV-I associated myelopathy in Canada. Can J Neurol Sci 16: 330–335

  33. 33.

    Cruickshank JK, Rudge P, Dalgleish AG, Newton M, McLean NB, Barnard RO, Kendall BE, Miller DH (1989) Tropical spastic paraparesis and human T-cell lymphotropic virus type I in the United Kingdom. Brain 112: 1057–1090

  34. 34.

    Manzani V, Gradilone A, Barillari G, Zani M, Collalti E, Pandolfi F, De Rossi G, Liso V, Babbo P, Robert-Guroff M, Frati L (1985) HTLV-I is endemic in Southern Italy: detection of the first infectious cluster in a white popution. Int J Cancer 36:557–559

  35. 35.

    Gout O, Gessain A, Bolgert F, Saal F, Tournier-Lasserve E, Lasneret J, Caudie C, Brunet P, De-The G, Lhermitte F, Lyon-Caen O (1989) Chronic myelopathies associated with human T-lymphotropic virus type I. A clinical, serologic, and immunovirologic study of ten patients in France. Arch Neurol 46: 255–260

  36. 36.

    Mani KS, Mani AJ, Montgomery RD (1969) A spastic paraplegic syndrome in South India. J Neurol Sci: 179–199

  37. 37.

    Armstrong MY, Hardy DB, Carlson JR, Friedlaender JS (1990) Prevalence of antibodies interactive with HTLV-I antigens in selected Solomon Islands populations. Am J Phys Anthropol 81: 465–470

  38. 38.

    Blattner WA, Nomura A, Clark JW, Ho GYF, Nakao Y, Gallo R (1986) Modes of transmission and evidence for viral latency from studies of HTLV-I in Japanese migrant populations in Hawaii. Proc Natl Acad Sci USA 83: 4895–4898

  39. 39.

    Shirabe S, Nakamura T, Tsujihata M, Nagataki S, Seiki M, Yoshida M (1990) Retrovirus from human T-cell leukemia virus type I-associated myelopathy is the same strain as a prototype human T-cell leukemia virus type I. Arch Neurol 47: 1258–1260

  40. 40.

    McFarlin D, Koprowski H (1990) Neurological disorders associated with HTLV-I. Curr Top Microbiol Immun 160: 100–119

  41. 41.

    Couderc L, Caubarrere I, Venet A, Magdeleine J, Jouanelle A, Danon F, Buisson G, Vernant JC (1988) Bronchoalveolar lymphocytosis in patients with tropical spastic paraparesis associated with human T-cell lymphotropic virus type I (HTLV-I). Ann Intern Med 109: 625–628

  42. 42.

    Wiley CA, Nerenberg M, Cros D, Soto-Aguilar MC (1989) HTLV-I polymyositis in a patient also infected with the human immunodeficiency virus. N Engl J Med 320: 992–995

  43. 43.

    Morgan OS, Rodgers-Johnson P, Mora C, Char G (1989) HTLV-I and polymyositis in Jamaica. Lancet II: 1184–1187

  44. 44.

    Nishioka K, Maruyama I, Sato K, Kitajima I, Nakajima Y, Osame M (1989) Chronic inflammatory arthropathy associated with HTLV-I. Lancet i: 441

  45. 45.

    Vernant JC, Buisson G, Magdeleine J, De Thore J, Jouannelle A, Neisson-Vernant C, Monplaisir M (1988) T-lymphocyte alveolitis, tropical spastic paraparesis, and Sjogren's. Lancet i: 177

  46. 46.

    Newton M, Cruickshank K, Miller D, Dalgleish A, Rudge P, Clayden S, Moseley I (1987) Antibody to human T-lymphotropic virus type I in West Indian-born UK residents with spastic paraparesis. Lancet i: 415–416

  47. 47.

    Kira J, Minato S, Itoyama Y, Goto I, Kato M, Hasuo K (1988) Leukoencephalopathy in HTLV-I-associated myelopathy: MRI and EEG data. J Neurol Sci 87: 221–232

  48. 48.

    Said G, Goulon-Goeau C, Lacroix C, Feve A, Descamps H, Fouchard M (1988) Inflammatory lesions of peripheral nerve in a patient with human T-lymphotropic virus type I-associated myelopathy. Ann Neurol 24: 275–277

  49. 49.

    Cortes E, Detels R, Aboulafia D, Li XL, Moudgil T, Alam M, Bonecker C, Gonzaga A, Oyafuso L, Tondo M, Boite C, Hammershlak N, Capitani C, Slamon DJ, Ho DD (1989) HIV-I, HIV-2, and HTLV-I infection in high-risk groups in Brazil. N Engl J Med 320: 953–958

  50. 50.

    Berger JR, Svenningsson A, Raffanti S, Resnick L (1991) Tropical spastic paraparesis-like illness occurring in a patient dually infected with HIV-I and HTLV-II. Neurology 41: 85–87

  51. 51.

    Murphy E, Figueroa P, Gibbs WN, Brathwaite A, Holding-Cobham Waters D, Cranston B, Hanchard B, Blattner WA (1989) Sexual transmission of human T-lymphotropic virus type I (HTLV-I). Ann Intern Med 111: 555–560

  52. 52.

    Saxton E, Lee HSwanson P, Chen ISY, Ruland C, Chin C, Aboulafia D, Delamarter R, Rosenblatt JD (1989) Detection of human T-cell leukemia/lymphoma virus type I in a transfusion recipient with chronic myelopathy. Neurology 39: 841–844

  53. 53.

    Osame M, Janssen R, Kubota H, Nishitani H, Igata A, Nagataki S, Mori M, Goto I, Shimabukuro H, Khabbaz R, Kaplan J (1990) Nationwide survey of HTLV-I-associated myelopathy in Japan: association with blood transfusion. Ann Neurol 28: 50–56

  54. 54.

    Kaplan J, Litchfield B, Roualt C, Lairmore MD, Luo CC, Williams L, Brew BJ, Price RW, Janssen R, Steneburner R, Ou CY, Folks T, De B (1991) HTLV-I-associated myelopathy associated with blood transfusion in the United States: epidemiologic and molecular evidence linking donor and recipient. Neurology 41: 192–197

  55. 55.

    Usuku K, Sonoda S, Osame M, Yashiki S, Takahashi K, Matsumoto M, Sawada T, Tsuji K, Tara M, Igata A (1988) HLA haplotype-linked high immune responsiveness against HTLV-I in HTLV-I-associated myelopathy: comparison with adult T-cell leukemia/lymphoma. Ann Neurol 23 [Suppl]: S 143-S 150

  56. 56.

    Akizuki S, Nakazato O, Higuchi Y, Tanabe K, Setoguchi M, Yoshida S, Miyazaki Y, Yamamoto S, Sudou S, Sannomiya K, Okajima T (1987) Necropsy findings in HTLV-I associated myelopathy. Lancet I: 156–157

  57. 57.

    Jacobs L, Kinkel WR, Polachini I, Kinkel PR (1986) Correlations of nuclear magnetic resonance imaging, computerized tomography, and clinical profiles in multiple sclerosis. Neurology 36: 27–34

  58. 58.

    Bydder GM (1984) Nuclear magnetic resonance imaging of the brain. Br Med Bull 40: 170–174

  59. 59.

    Poser CM, Roman GC, Vernant JC (1990) Multiple sclerosis or HTLV-I myelitis?. Neurology 40: 1020–1022

  60. 60.

    Kermode AG, Rudge P, Thompson AJ, Du Boulay EP, McDonald WI (1990) MRI of thoracic cord in tropical spastic paraparesis. J Neurol Neurosurg Psychiatry 53: 710

  61. 61.

    Paty DW, McFarlin DE, McDonald WI (1991) Magnetic resonance imaging and laboratory aids in the diagnosis of multiple sclerosis. Ann Neurol 29: 3–4

  62. 62.

    Paty DW, Asbury KA, Herndon RM, McFarland HF, McDonald WI, McIlroy WJ, Prineas JW, Scheinberg LC, Wolinsky JS (1986) Use of magnetic resonance imagning in the diagnosis of multiple sclerosis: policy statement. Neurology 36: 1575

  63. 63.

    Hara Y, Takahashi M, Ueno S, Yoshikawa H, Yorifuji S, Tarui S (1988) MR imaging of the brain in myelopathy associated with human T-cell lymphotropic virus type I. J Comput Assist Tomogr 12: 750–754

  64. 64.

    Rao SM, Leo GJ, Haughton VM, St. Aubin-Faubert P, Bernadin L (1989) Correlation of magnetic resonance imaging with neuropsychological testing in multiple sclerosis. Neurology 39:161–166

  65. 65.

    Franklin GM, Heaton RK, Nelson LM, Filley CM, Seibert C (1988) Correlation of neuropsychological and MRI findings in chronic/progressive multiple sclerosis. Neurology 38: 1826–1829

  66. 66.

    Fazekas F, Offenbacher H, Fuchs S, Schmidt R, Niederkorn K, Horner S, Lechner H (1988) Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis. Neurology 38: 1822–1825

  67. 67.

    Koopmans R, Li DKB, Oger LJF, Mayo J, Paty DW (1989) The lesion of multiple sclerosis: Imaging of acute and chronic stages. Neurology 39: 959–963

  68. 68.

    Oger J, Kastrukoff LF, Li DKB, Paty DW (1988) Multiple sclerosis: in relapsing patients, immune functions vary with disease activity as assessed by MRI. Neurology 38:1739–1744

  69. 69.

    Willoughby EW, Grochowski E, Li DKB, Oger J, Kastrukoff LF, Paty DW (1989) Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients. Ann Neurol 25: 43–49

  70. 70.

    Isaac C, Li DKB, Genton M, Jardine C, Grochowski E, Palmer M, Kastrukoff LF, Oger J, Paty DW (1988) Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 38: 1511–1515

  71. 71.

    Paty DW, Blume WT, Brown WF, Jaatoul N, Kertesz A, Mcinnis W (1979) Chronic progressive myelopathy: investigation with CSF electrophoresis, evoked potentials, and CT scan. Ann Neurol 6: 419–424

  72. 72.

    Farlow MR, Markand ON, Edwards MK, Stevens JC, Kolar OJ (1986) Multiple sclerosis: magnetic resonance imaging, evoked responses, and spinal fluid electrophoresis. Neurology 36: 828–831

  73. 73.

    Farlow MR, Edwards MK, Kolar OJ, Stevens JC, Yu PI (1987) Magnetic resonance imaging in multiple sclerosis: analysis of correlations to peripheral blood and spinal fluid abnormalities. Neurology 37: 1527–1530

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Alcindor, E., Valderrama, R., Canavaggio, M. et al. Imaging of human T-lymphotropic virus type I-associated chronic progressive myeloneuropathies. Neuroradiology 35, 69–74 (1992). https://doi.org/10.1007/BF00588283

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Key words

  • Chronic progressive myeloneuropathy
  • Human T-lymphocytic virus type I (HTLV-I)-associated myelopathy
  • Tropical spastic paraparesis
  • Magnetic resonance imaging
  • Computed tomography