, Volume 35, Issue 1, pp 10–15 | Cite as

Cerebrospinal fluid flow

II. Physiology of respiration-related pulsations
  • G. Schroth
  • U. Klose
Diagnostic Neuroradiology


Cerebrospinal fluid (CSF) flow in the cerebral aqueduct and spinal canal was analysed using real-time magnetic resonance imaging measurement techniques. Respiration-induced rhythmic modulation of the cardiacrelated oscillating CSF pulsation in the cerebral aqueduct and spinal canal was found. Deep inspiration was immediately followed by a marked increase in downward CSF flow in the cervical spinal canal, whereas a delay of about two heart beats was seen before downward flow from the third to the fourth ventricle increased. This pattern was also detected during yawning and was followed by a marked increase of blood flow in the internal jugular vein.

Key words

Cerebrospinal fluid flow Magnetic resonance imaging Real time Yawning 


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  1. 1.
    Bergstrand G, Bergstroem M, Nordell B, et al (1985) Cardiac gated MR imaging of cerebrospinal fluid flow. J Comput Assist Tomogr 9: 1003–1006Google Scholar
  2. 2.
    Feinberg DA, Marks AS (1987) Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging. Radiology 163:793–799Google Scholar
  3. 3.
    Quencer RM, Post MD, Hinks RS (1990) Cine MR in the evaluation of normal and abnormal CSF flow: intracranial and intraspinal studies. Neuroradiology 32: 371–391Google Scholar
  4. 4.
    Schroth G, Klose U, Gawehn J, Petersen D, Varallay G (1987) ECG-related pulsations of the CSF. Society of Magnetic Resonance in Medicine, 6th Annual Meeting, New York, Book of Abstracts, p 119Google Scholar
  5. 5.
    Schroth G, Klose U, Grodd W (1989) Spinal CSF pulsations. In: Nadjimi M (ed) Imaging of brain metabolism, spine and cord, Springer, Berlin Heidelberg New York, pp 53–58Google Scholar
  6. 6.
    Schroth G, Klose U (1992) Cerebrospinal flow. I. Physiology of cardiac-related pulsations. Neuroradiology 35: 1–9Google Scholar
  7. 7.
    Knoll P (1886) Ueber die Druckschwankungen in der Cerebrospinalfluessigkeit und den Wechsel in der Blutfuelle des centralen Nervensystems. Sitzungsber Kaiserl Akad Wiss Wien Math-Naturwiss Classe 1886: 217–248Google Scholar
  8. 8.
    Becher E (1919) Beobachtungen ueber die Abhaengigkeit des Lumbaldruckes von der Kopfhaltung. Dtsch Z Nervenheilkd 63: 89–96Google Scholar
  9. 9.
    Becher E (1924) Ueber Druckverhaeltnisse im Liqour cerebrospinalis. Grenzgeb Med Chir 35: 324–332Google Scholar
  10. 10.
    Di Chiro G (1964) Movement of the cerebrospinal fluid in human beings. Nature 204: 290–291Google Scholar
  11. 11.
    Di Chiro G (1966) Observations on the circulation of the cerebrospinal fluid. Acta Radiol 5: 988–1002Google Scholar
  12. 12.
    Di Chiro G, Hammock MK, Bleyer WA (1976) Spinal descent of cerebrospinal fluid in man. Neurology 26: 1–8Google Scholar
  13. 13.
    Du Boulay GH (1966) Pulsatile movements in the CSF pathways. Br J Radiol 39: 255–262Google Scholar
  14. 14.
    Du Boulay GH, O'Connell J, Currie J, Bostick T, Verity P (1972) Further investigations on pulsatile movements in the cerebrospinal fluid pathways. Acta Radiol 13: 496–523Google Scholar
  15. 15.
    Klose U, Schroth G, Mueller E, Grodd W (1988) Echtzeit-Darstellungsmoeglichkeiten von Liquorbewegungen in der Kernspintomographie. In: Nüsslin F (ed) Medizinische Physik. Deutsche Gesellschaft fuer Med. Physik, Tübingen, pp 562–567Google Scholar
  16. 16.
    Mueller E, Laub G, Graumann R, Loeffler W (1988) RACE-real time acquisition and evaluation of pulsatile blood flow on a whole body MRI unit. Society of Magnetic Resonance in Medicine, 7th Annual Meeting, San Francisco, Book of Abstracts, p 729Google Scholar
  17. 17.
    Quinke H (1877) Ueber den Druck in Transsudaten. Arch Klin Med 21: 453–468Google Scholar
  18. 18.
    Ewig W, Lullies H (1924) Der Einfluss der Atmung auf die Druckschwankungen im Cerebrospinalkanal. Z Exp Med 43: 764–781Google Scholar
  19. 19.
    Fleck U (1932) Zur Bewertung des Liquordrucks. Dtsch Med Wochenschr 1: 737–740Google Scholar
  20. 20.
    Ewig W, Lullies H (1924) Ueber die pulsatorischen Druckschwankungen im Lumbalkanal. Z Exp Med 43: 782–790Google Scholar
  21. 21.
    Sharpey-Schafer EP (1965) Effect of respiratory acts on the circulation. In: Hamilton WF, Dow P (eds) Physiology, section 2, vol 3. Circulation. Waverly Press, Baltimore, pp 1875–1886Google Scholar
  22. 22.
    Milhorat TH (1975) The third circulation revisited. J Neurosurg 42: 628–645Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. Schroth
    • 1
    • 2
  • U. Klose
    • 1
  1. 1.Department of NeuroradiologyUniversity of TübingenFederal Republic of Germany
  2. 2.Department of NeuroradiologyEberhard-Karls-UniversitätTübingenFederal Republic of Germany

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