Genotypenfrequenzen und Vererbung im MNSs-System, zugleich ein Beitrag über die Verwendbarkeit der Merkmale S und s im Blutgruppengutachten

  • W. Spielmann
  • H. Ruppin
  • L. Schilling
  • D. Teixidor
Article
Received:

Summary

The determination of the antigens in the MNSs-system, preferably of s, is connected with serveral sources of errors which may be of importance in frequency and family studies as well as in medicolegal work. For s-testing several suitable anti-s sera which give strong reactions (+++ or ++++) with heterozygous control cells should be used and red cell damages by storage or heating during transport which influence the results to a greater extent than in most the other antigens should be strictly avoided.

Further sources of errors, rare occuring in the white population and only influencing paternity exclusions based on opposite homozygosity of the allels S and s, are weakened s-antigens and a third allele on the S/slocus. The latter possibility may be recognized by dosage tests, since rare allels only give a single dosis of S, resp. s, similar as the heterozygous Ss-types. The two distribution curves of scores differ more than the threefold standard deviation. Heterozygous Su-types were found only 4 times in our studies on white persons in a single Hessian family, but 49 times in 484 Bantu-negroes.

Gene frequencies were calculated from a collective of 2532 unrelated persons of Hessia and of 484 negroes living in southern Mocambique. The calculated genotype values are in a good agreement with the observed values.

Complete MNSs-phenotyping in 303 unselected families with 606 children showed no case of contradiction against the hereditary rules.

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Copyright information

© Springer-Verlag 1968

Authors and Affiliations

  • W. Spielmann
    • 1
    • 2
  • H. Ruppin
    • 1
    • 2
  • L. Schilling
    • 1
    • 2
  • D. Teixidor
    • 1
    • 2
  1. 1.Abteilung für Immunhämatologie und Transfusionskunde der Universität Frankfurt a. M.Deutschland
  2. 2.Blutspendedienst des Deutschen Roten KreuzesHessen

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