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Postprandial changes of renal blood flow

Studies on conscious dogs on a high and low sodium intake

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Summary

Postprandial renal blood flow was studied in 14 conscious dogs on a chronic high and low sodium intake on 72 days after implantation of an electromagnetic flow transducer around the left renal artery. Fasting renal blood flow was 11.7±3.2 ml/min·kg on high sodium intake (43 days) and 11.5±3.3 ml/min·kg on low sodium intake (29 days). During ingestion no change of renal blood flow occurred; mean arterial pressure rose transiently. During digestion renal blood flow increased always and was, like the fasting renal blood flow, independent of the daily sodium intake: maximum increase of renal blood flow of dogs on a high sodium intake was 41±23%, and of dogs on a low sodium intake 35±155 referring to fasting controls; peak increase mostly occurred between 60 and 90 min postprandially and was due to a decrease of renal vascular resistance.

Renal blood flow also increased after augmentation of intravascular volume by an intravenous infusion; volume receptors may be involved.

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Reinhardt, H.W., Kaczmarczyk, G., Fahrenhorst, K. et al. Postprandial changes of renal blood flow. Pflugers Arch. 354, 287–297 (1975). https://doi.org/10.1007/BF00587848

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Key words

  • Renal Blood Flow
  • Conscious Dogs
  • High and Low Sodium Intake
  • Postprandial