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Presynaptic inhibition of long duration at crab neuromuscular junctions

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In the closer muscle of various decapod crustaceans interjection of a single train of stimuli applied to the inhibitory axon causes long lasting depression of the contractions elicited by subsequent stimulations of the “slow” excitatory axon. This phenomenon of postinhibitory depression (PID) is due to long lasting presynaptic action of the inhibitory transmitter. Its duration differs from that of the postsynaptic inhibitory effects by at least one order of magnitude: the conductance increase of the postsynaptic membrane may last at most a few sec after cessation of an I-train, the presynaptic reduction of excitatory transmitter output, however, up to several min.

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Supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich 138).

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Rathmayer, W., Florey, E. Presynaptic inhibition of long duration at crab neuromuscular junctions. Pflugers Arch. 348, 77–81 (1974). https://doi.org/10.1007/BF00587741

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Key words

  • Crustacean Muscle
  • Presynaptic Inhibition
  • Postinhibitory Depression