Pflügers Archiv

, Volume 326, Issue 4, pp 324–333 | Cite as

Bulbar inhibition of spinal and supraspinal sympathetic reflex discharges

  • F. Kirchner
  • A. Sato
  • H. Weidinger


  1. 1.

    In chloralose anesthetized cats, the sympathetic reflex discharge was recorded from the renal sympathetic nerve.

  2. 2.

    The early-spinal and late-supraspinal sympathetic reflex discharges were elicited by single electrical stimulation of the thoracic dorsal roots.

  3. 3.

    Increased excitation of the baroceptor afferents produced by a rise of blood pressure after injection of noradrenaline caused strong inhibitition of the latesupraspinal reflex discharge. The early-spinal reflex discharge was only rarely affected.

  4. 4.

    Electrical stimulation of the medullary depressor area caused inhibition of the spinal and supraspinal reflex discharges.

  5. 5.

    It is concluded that spinal reflex pathways receive some inhibitory descending influences from the medulla oblongata.



Renal Sympathetic Reflex Spinal Sympathetic Reflex Supraspinal Sympathetic Reflex Noradrenaline Baroceptor Afferent Stimulation Inhibitory Descending Pathways 


Sympathische Reflexe Spinale sympathische Reflexe Supraspinale sympathische Reflexe Noradrenalin Bulbäre depressorische Reizung Hemmende absteigende Fasern 


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  1. Adrian, E. D., Bronk, D. W., Phillips, G.: Discharges in mammalian sympathetic nerves. J. Physiol. (Lond.)74, 115–133 (1932).Google Scholar
  2. Alexander, R. S.: Tonic and reflex functions of medullary sympathetic cardiovascular centers. J. Neurophysiol.9, 205–217 (1946).Google Scholar
  3. Andén, N. G., Jukes, M. G. M., Lundberg, A., Vyklicky, L.: The effect of DOPA on the spinal cord. I. Influence on transmission from primary afferents. Acta physiol. scand.67, 373–386 (1966).PubMedCrossRefGoogle Scholar
  4. Baust, W., Niemczyk, H.: Studies on the adrenaline-sensitive component of the mesencephalic reticular formation. J. Neurophysiol.26, 692–704 (1963).PubMedGoogle Scholar
  5. Beacham, W. S., Perl, E. R.: Background and reflex activity of sympathetic preganglionic neurones in spinal cat. J. Physiol. (Lond.)172, 400–416 (1964).Google Scholar
  6. Christensen, K., Lewis, E., Kuntz, A.: Innervation of the renal blood vessels in the cat. J. comp. Neurol.95, 373–386 (1951).PubMedCrossRefGoogle Scholar
  7. Coote, J. H., Downman, C. B. B.: Central pathways of some autonomic reflex discharges. J. Physiol. (Lond.)183, 714–729 (1966).Google Scholar
  8. ——: Supraspinal control of reflex activity in renal nerves. J. Physiol. (Lond.)202, 161–170 (1969).Google Scholar
  9. —— Weber, W. V.: Reflex discharges into thoracic white rami elicited by somatic and visceral afferent excitation. J. Physiol. (Lond.)202, 147–159 (1969).Google Scholar
  10. De Groat, W. C., Ryall, R. W.: An excitatory action of 5-hydroxytryptamine on sympathetic preganglion neurones. Exp. Brain Res.3, 299–305 (1967).PubMedCrossRefGoogle Scholar
  11. Gernandt, B., Liljestrand, G., Zotterman, Y.: Efferent impulses in the splanchnic nerves. Acta physiol. scand.11, 230–247 (1946).Google Scholar
  12. Jänig, W., Schmidt, R. F.: Single unit responses in the cervical sympathetic trunk upon somatic nerve stimulation. Pflügers Arch.314, 199–216 (1970).PubMedCrossRefGoogle Scholar
  13. Kedzi, P.: Control by the superior cervical ganglion of the state of contraction and pulsatile expansion of the carotid sinus arterial wall. Circulat. Res.2, 367–371 (1954).Google Scholar
  14. Niijima, A., Winter, D. L.: The effect of catecholamines on unit activity in afferent nerves from the adrenal glands. J. Physiol. (Lond.)195, 647–656 (1968).Google Scholar
  15. Pitts, R. F., Larrabee, M. G., Bronk, D. W.: Hypothalamic cardiovascular control. Amer. J. Physiol.134, 359–383 (1941).Google Scholar
  16. Sato, A., Kaufman, A., Koizumi, K., Brooks, C. McC.: Afferent nerve groups and sympathetic reflex pathways. Brain Res.14, 575–587 (1969).PubMedCrossRefGoogle Scholar
  17. — Schmidt, R. F.: Spinal and supraspinal components for the reflex discharges into lumbar and thoracic white rami. J. Physiol. (Lond.)212, 839–850 (1971).Google Scholar
  18. — Tsushima, N., Fujimori, B.: Reflex potentials of lumbar sympathetic trunk with sciatic nerve stimulation in cats. Jap. J. Physiol.15, 532–539 (1965).Google Scholar
  19. Selkurt, E. E.: The renal circulation. Handbook of physiology, Section 2, Vol. II, pp. 1457–1516. Washington: Amer. Physiol. Soc. 1963.Google Scholar
  20. Sell, R., Erdely, A., Schaefer, H.: Untersuchungen über den Einfluß peripherer Nervenreizung auf die sympathische Aktivität. Pflügers Arch. ges. Physiol.267, 566–581 (1958).CrossRefGoogle Scholar
  21. Weidinger, H.: Das Vasomotorenzentrum in der Medulla oblongata. Versuche zur Bestimmung seiner Lage und Funktion. Habilitationsschrift, Univ. Heidelberg 1966.Google Scholar
  22. —, Fedina, L., Kehrel, H.: Der Einfluß von Adrenalin auf die Tätigkeit des Sympathicus. Pflügers Arch. ges. Physiol.278, 229–240 (1963).CrossRefGoogle Scholar
  23. ——— Schaefer, H.: Über die Lokalisation des bulbaren, sympathischen Zentrums und über seine Beeinflussung durch die Atmung und Blutdruck. Z. Kreisl.-Forsch.50, 229–241 (1961).Google Scholar
  24. — Sato, A., Kirchner, F.: Depressorischer Einfluß auf die bulbäre und spinale segmentale sympathische Reflexe. Pflügers Arch. ges. Physiol.291, R6–7 (1966).Google Scholar

Copyright information

© Springer-Verlag 1971

Authors and Affiliations

  • F. Kirchner
    • 1
  • A. Sato
    • 1
  • H. Weidinger
    • 1
  1. 1.I. Physiologisches Institut der Universität HeidelbergHeidelbergGermany

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