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Determination of segmental resistances in the canine kidney

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Summary

Series connected segmental resistances in the normal canine kidney were studied under free flow and under stop flow conditions. For the calculation of glomerular capillary pressure equation GFR =k (p glp irp co) has been used. The permeability constant (k) was determined under the assumption that below the autoregulatory rangep gl=p art; supposing the independence ofk of perfusion pressure,p gl could be calculated at any arterial pressure. Intrarenal deep venous pressure equals proximal tubular and peritubular capillary pressures in free flow; stabilized ureter occlusion pressure measures intrarenal pressures in stop flow.

The procedure enables the determination of glomerular capillary pressure without recurring to ureter occlusion. Thusp gl amounts to 88 mm Hg (free flow) and 96 mm Hg (stop flow) whereas the tranditional manner of calculation (p ur-stop+p co) yields 73 mm Hg for both conditions. Owing to intense residual filtrationp gl exceedsp ur-stop+p co even under stop flow conditions.

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Bálint, P., Fekete, A., Molnár, L. et al. Determination of segmental resistances in the canine kidney. Pflugers Arch. 327, 274–284 (1971). https://doi.org/10.1007/BF00586863

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Key-Words

  • Renal Resistance
  • Glomerular Capillary Pressure
  • Glomerular Permeability Coefficient
  • Intrarenal Pressure Drop