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Effects of an anabolic hormone on striated muscle growth and performance

  • S. Egginton
Heart, Circulation, Respiration and Blood Environmental and Exercise Physiology

Abstract

Chronic administration of an anabolic hormone, nandrolone phenylpropionate, in sedentary female rats for 6 weeks gave a 20% increase in body weight and the same proportional increase in all muscles sampled (heart, diaphragm, soleus, TA, EHP and EDL), such that the muscle/body weight ratio was unchanged. Cardiac muscle was unresponsive to treatment. Acute stimulation of EDL via lateral popliteal nerve gave similar values for contraction time, 1/2 relaxation time and twitch: tetanus ratio in both groups suggesting no slowing of the muscle. Fatigue resistance of EDL was improved with 0.29±0.029 vs. 0.46±0.071 of maximum isometric twitch tension being developed after 10 min repetitive stimulation at 4 Hz. This improved endurance was not accompanied by any increase in strength and could not be explained on the basis of cellular hypertrophy, but appears to reflect an increased aerobic capacity of skeletal muscle. The proportion of FOG fibres in EDL increased, 38±1.1% vs. 46±1.1%, and this was paralleled in the other skeletal muscles. Specific hypertrophy of FOG and FG fibres could be conclusively demonstrated in soleus and TA, respectively.

Key words

Nandrolone phenylpropionate Durabolin Striated muscle Fibre types Growth Endurance 

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References

  1. Alén M, Häkkinen K, Komi PV (1984) Changes in neuromuscular performance and muscle fibre characteristics of elite power athleties self-administering androgenic and anabolic steroids. Acta Physiol Scand 122:535–544CrossRefPubMedGoogle Scholar
  2. Boris A, Stevenson RH, Trmal T (1970) Comparative androgenic, myotrophic and antigonadotrophic properties of some anabolic steroids. Steroids 15:61–71CrossRefPubMedGoogle Scholar
  3. Breuer CB, Florini JR (1965) Amino acid incorporation into protein by cell-free systems from rat skeletal muscle. Biochemistry 4:1544–1550CrossRefPubMedGoogle Scholar
  4. Chaudry MAQ, James KC, Ng CT, Nicholls PJ (1976) Anabolic and androgenic activities, in rats, of some nandrolone and androstandone esters. J Pharm Pharmacol 28:882–885CrossRefPubMedGoogle Scholar
  5. Dahlberg E, Snochowski M, Gustafsson J-Å (1981) Regulation of the androgen and glucocorticoid receptors in rat and mouse skeletal muscle cytosol. Endocrinology 108:1431–1440CrossRefPubMedGoogle Scholar
  6. Döhler KD, Wuttke W (1975) Changes with age in levels of serum gonadotropins, prolactin, and gonadal steroids in pre-pubertal male and female rats. Endocrinology 97:898–907CrossRefPubMedGoogle Scholar
  7. Egginton S (1986) Effects of an anabolic hormone on performance and composition of rat skeletal muscle. J Physiol 373:35PGoogle Scholar
  8. Egginton S (1987) Effects of an anabolic hormone on aerobic capacity of rat striated muscle. Pflügers Arch 410:356–361CrossRefPubMedGoogle Scholar
  9. Exner GU, Staudte HW, Pette D (1973a) Isometric training of rats — effects upon fast and slow muscle and modification by an anabolic hormone (nandrolone decanoate). I. Female rats. Pflügers Arch 345:1–14CrossRefPubMedGoogle Scholar
  10. Exner GU, Staudte HW, Pette D (1973b) Isometric training of rats — effects upon fast and slow muscle and modification by an anabolic hormone (nandrolone decanoate). II. Male rats. Pflügers Arch 345:15–22CrossRefPubMedGoogle Scholar
  11. Fahley TD, Brown CH (1973) The effects of an anabolic steroid on the strength, body composition and endurance of college males when accompanied by a weight training program. Med Sci Sprots Exerc 5:272–276Google Scholar
  12. Freed DLJ, Banks AJ, Longston D, Burley DM (1975) Anabolic steroids in athletes: crossover double-blind trial on weight-lifters. Br Med J 2:477–473Google Scholar
  13. Goldberg AL, Tischler M, DeMartino G, Griffin G (1980) Hormonal regulation of protein degradation and synthesis in skeletal muscle. Fed Proc 39:31–36PubMedGoogle Scholar
  14. Gustafsson J-Å, Saartok T, Dahlberg E, Snochowski M, Häggmark T, Eriksson E (1984) Studies on steroid receptors in human and rabbit skeletal muscle — clues to the understanding of the mechanism of action of anabolic steroids. In: Gurpide E, Calandra LC, Soto RJ (eds) Hormones and Cancer. Liss, New York, pp 261–290Google Scholar
  15. Hanzliková V, Gutman E (1974) The absence of androgen-sensitivity in the grafted soleus muscle innervated by the pudendal nerve. Cell Tiss Res 154:121–129CrossRefGoogle Scholar
  16. Hervey GR, Hutchinson I (1973) The effects of testosterone on body weight and composition in the rat. J Endocrinol 57:XXIVGoogle Scholar
  17. Hickson RC, Hensner WW, Van Huss WD, Taylor JF, Carrow RE (1976) Effects of an anabolic steroid and sprint training on selected histochemical and morphological observations in rat skeletal types. Eur J Applied Physiol 35:251–259CrossRefGoogle Scholar
  18. Hickson RC, Galassi TM, Kurowski TT, Daniels DG, Chatterton RT (1984) Androgen and glucocorticoid mechanisms in exereise-induced cardiac hypertrophy. Am J Physiol 246:H761-H767PubMedGoogle Scholar
  19. Hudlická O, Dodd L, Renkin EM, Gray SD (1982) Early changes in fibre profiles and capillary density in long-term stimulated muscles. Am J Physiol 243:H528-H535PubMedGoogle Scholar
  20. Hutchinson IWW, Schantz P, Åstrand P-O, Bevan L (1983) Muscle fibre type distribution, muscle cross-sectional area and serum androgens. Med Sci Sports Exerc 15:176CrossRefGoogle Scholar
  21. James KC, Nicholls PJ, Roberts M (1969) Biological half-lives of [4-14C] testosterone and some of its esters after injection into the rat. J Pharm Pharmacol 21:24–27CrossRefPubMedGoogle Scholar
  22. Johnson LC, O'Shea JP (1969) Anabolic steroid effects on strength development. Science 164:957–959CrossRefPubMedGoogle Scholar
  23. Kelly FJ, McGrath JA, Goldspink DF, Cullen MJ (1986) A morphological/biochemical study on the actions of corticosteroids on rat skeletal muscle. Muscle Nerve 9:1–10CrossRefPubMedGoogle Scholar
  24. Keul J, Deus B, Kindermann W (1976) Anabole Hormone: Schädigung, Leistungsfähigkeit und Stoffwechsel. Med Klin 71:497–503PubMedGoogle Scholar
  25. Kuhn FE, Max SR (1985) Testosterone and muscle hypertrophy in female rats. J Appl Physiol 59:24–27PubMedGoogle Scholar
  26. Max SR, Rance NE (1984) No effect of sex steroids on compensatory muscle hypertrophy. J Appl Physiol 56:1589–1593PubMedGoogle Scholar
  27. Millward DJ, Garlick PJ, Nnanyelugo DO (1976) The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass. Biochem J 156:185–188CrossRefPubMedPubMedCentralGoogle Scholar
  28. Müntener M (1979) Variable pH dependence of the myosin-ATPase in different muscles of the rat. Histochemistry 62:299–304CrossRefPubMedGoogle Scholar
  29. Nachlas MM, Tsou K, Desonsa G, Cheng C, Seligman A (1957) Cytochemical demonstration of SDH by the use of a new p-nitrophenol substituted derivative. J Histochem Cytochem 5:420–436CrossRefPubMedGoogle Scholar
  30. Overbeek GA, van der Vies J, de Visser J (1969) The so-called “pure” anabolic agents. J Am Med Wom Assoc 24:54–59PubMedGoogle Scholar
  31. Papanicolaou GN, Falk EA (1938) General muscular hypertrophy induced by androgenic hormone. Science 87:238–239CrossRefPubMedGoogle Scholar
  32. Pearse AGE (1968) Histochemistry, theoretical and applied. 3rd edn, Churchill Livingstone, Edinburgh London New YorkGoogle Scholar
  33. Pullen AH (1977) The distribution and relative sizes of fibre types in the extensor digitorum longus and soleus muscles of the adult rat. J Anat 123:467–486PubMedPubMedCentralGoogle Scholar
  34. Rothstein JM, Rose SJ (1982) Muscle mutability. Part 2 Adaption to drugs, metabolic factors and aging. Phys Ther 62:1788–1798PubMedGoogle Scholar
  35. Ryan AJ (1981) Anabolic steroids are fool's gold. Fed Proc 40:2682–2688PubMedGoogle Scholar
  36. Saartok T, Dahlberg E, Gustafsson J-Å (1984) Relative binding affinity of anabolic and androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex-hormone binding globulin. Endocrinology 114:2100–2106CrossRefPubMedGoogle Scholar
  37. Salmons S (1983) Myotrophic effects of anabolic steroids. Vet Res Commun 7:19–26CrossRefPubMedGoogle Scholar
  38. Stone MH, Lipner H (1978) Responses to intensive training and methandrostenelone administration. I. Contractile and performance variables. Pflügers Arch 375:141–146CrossRefPubMedGoogle Scholar
  39. Tóth M, Zakár T (1982) Relative binding affinities of testosterone, 19-nortestosterone and their 5α-reduced derivatives to the androgen receptor and to other androgen-binding proteins. J Steroid Bichem 17:653–660CrossRefGoogle Scholar
  40. van der Vies J (1970) Model studies in vitro with long-acting hormonal preparations. Acta Endocrinol 64:656–669PubMedGoogle Scholar
  41. Viru A, Korge P (1979) Role of anabolic steroids in the hormonal regulation of skeletal muscle adaption. J Steroid Biochem 11:931–932CrossRefPubMedGoogle Scholar
  42. Wright JE (1980) Anabolic steroids and athletes. In: Hutton RS, Miller DI (eds) Exercise and Sport Sciences Reviews, vol 8. Franklin Institute Press, Philadelphia, PA, pp 149–202Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • S. Egginton
    • 1
  1. 1.Department of Physiology, Medical SchoolUniversity of BirminghamBirminghamUK

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