Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The Hering-Breuer reflexes in the bronchial asthma attack

  • 58 Accesses

  • 6 Citations

Summary

The correlation between pulmonary stretch receptor activity and inspiration-expiration duration quotient, as well as respiratory frequency (Hering-Breuer relfexes) has been established before and during an asthma attack in the guinea-pig

The Hering-Breuer reflexes subserving the self-regulation of breathing during uninfluenced spontaneous breathing no longer prevail after induction of a bronchial asthma attack. Increased stretch receptor activity following increased lung volume does not lead to inhibition of inspiratory activity (lung inflation reflex), but to an enhancement of the asthmatic tachypnoea. The latter is assumed to result from the expiratory self-compression of the lungs (lung deflation reflex).

The enhancement of the deflation reflex by increasing lung volume during the asthma attack is discussed with regard to the unerven ventilation and the conditions in lung mechanics underlying the excitation of the lung deflation or collapse endings.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Breuer, J.: Die Selbststeuerung der Athmung durch den Nervus vagus. S.-B. Akad. Wiss. Wien58 (II), 909–937 (1868)

  2. 2.

    Bucher, K.: Reflektorische Beeinflußbarkeit der Lungenatmung. Wien: Springer 1952

  3. 3.

    Buff, R., Koller, E. A.: Studies on mechanisms underlying the reflex hyperpnoea induced by inhalation of chemical irritants. Resp. Physiol.21, 371–383 (1974)

  4. 4.

    Ferrer, P., Koller, E. A.: Über die Vagusafferenzen des Meerschweinchens und ihre Bedeutung für die Spontanatmung. Helv. physiol. pharmacol. Acta26, 365–387 (1968/69)

  5. 5.

    Glogowska, M., Widdicombe, J. G.: The role of vagal reflexes in experimental lung oedema, bronchoconstriction and inhalation of halothane. Respir. Physiol.18, 116–128 (1973)

  6. 6.

    Hering, E.: Die Selbststeurung der Athmung durch den Nervus vagus. S.-B. Akad. Wiss. Wien57 (II), 672–677 (1868)

  7. 7.

    Karczewski, W.: The electrical activity of the vagus nerve in anaphylactic shock. Acta Allerg. (Kbh.)17, 334–342 (1962)

  8. 8.

    Koller, E. A.: Atmung und Kreislauf im anaphylaktischen Asthma bronchiale des Meerschweinchens. II. Die Bedeutung des N. vagus für die Atmungs- und Kreislaufreaktionen. Helv. physiol. pharmacol. Acta25, 353–373 (1967)

  9. 9.

    Koller, E. A., Ferrer, P.: Studies on the role of the lung deflation reflex. Respir. Physiol.10, 172–183 (1970)

  10. 10.

    Koller, E. A., Ferrer, P.: Discharge patterns of the lung stretch receptors and activation of deflation fibres in anaphylactic bronchial asthma. Respir. Physiol.17, 113–126 (1973)

  11. 11.

    Koller, E. A., Rüegg, D. G., Ferrer, P.: Approach to a quantitative differentiation between the respiratory effects evoked from the lung stretch and the lung deflation receptors during thoracic compression. Experientia (Basel)27, 163–164 (1971)

  12. 12.

    Mills, J. E., Sellick, H., Widdicombe, J. G.: Activity of lung irritant receptors in pulmonary microembolism, anaphylaxis and drug-induced bronchoconstrictions. J. Physiol. (Lond.)203, 337–357 (1969)

  13. 13.

    Oberholzer, R. J. M., Ricci, G., Steiner, F. A.: Vagale Atmungsreflexe beim Meerschweinchen. Helv. physiol. pharmacol. Acta13, 195–206 (1955)

  14. 14.

    Widdicombe, J. G.: The site of pulmonary stretch receptors in the cat. J. Physiol. (Lond.)125, 336–351 (1954)

  15. 15.

    Widdicombe, J. G.: The activity of pulmonary stretch receptors during bronchoconstriction, pulmonary oedema, atelectasis and breathing against a resistance. J. Physiol. (Lond.)159, 436–450 (1961)

  16. 16.

    Widdicombe, J. G.: Respiratory reflexes. In: Handbook of Physiology, Section 3: Respiration, Vol. I, edit. by W. O. Fenn and H. Rahn. Washington, D.C.: American Physiological Society 1964

  17. 17.

    Wyss, O. A. M.: Reizphysiologische Analyse des afferenten Lungenvagus. Pflügers Arch. ges. Physiol.242, 215–233 (1939)

  18. 18.

    Wyss, O. A. M.: Die nervöse Steuerung der Atmung. Ergebn. Physiol.54, 1–479 (1964)

  19. 19.

    Wyss, O. A. M., Koller, E. A.: Die inspiratorische Reaktion als Abwehrmechanismus des Atmungsapparates. Beitr. Klin. Tuberk.138, 243–249 (1968)

  20. 20.

    Wyss, O. A. M., Rivkine, A.: Les fibres afférentes du nerf vague participant aux réflexes respiratoires. Helv. physiol. pharmacol. Acta8, 87–106 (1950)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Koller, E.A., Kohl, J. The Hering-Breuer reflexes in the bronchial asthma attack. Pflugers Arch. 357, 165–171 (1975). https://doi.org/10.1007/BF00585972

Download citation

Key words

  • Pulmonary Stretch Receptor Activity
  • Self-regulation of Breathing
  • Asthma Attack
  • Uneven Ventilation
  • Lung Deflation Reflex